Sitagliptin powder

Supply API Sitagliptin powder with CAS 486460-32-6

Igama lemveliso:
Sitagliptin powder
Ibakala:
Pharmaceutical grade
Iinkcazelo ngeempawu:
umgubo omhlophe
Ukupakisha:
25kg/igubu
MOQ:
1 kilo
Ugcino:Indawo eyomileyo epholileyo
Beka ubomi kwishelufa:iminyaka eyi-2

QHAGAMSHELANA NGOKU PDF Khuphela

Iinkcukacha

Iithegi

Ingcaciso yeMveliso

Sitagliptin is an oral antihyperglycemic of the dipeptidyl peptidase-4 inhibitor class. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents for treatment of diabetes mellitus type 2.The benefit of this medicine is its fewer side effects in the control of blood glucose values. While safety is its advantage, efficacy is often challenged as it is often recommended to be combined with other agents such as metformin.

Isicelo

Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that controls blood glucose levels by protecting and enhancing endogenous enteroglycin.Glucose-dependent insulin-releasing peptides (GIP) and glucagon-like peptide-1 (GLP-1) are enteroglycins released in response to dietary intake.

GLP-1 and GIP can increase insulin synthesis and release from islet β cells through intracellular signaling pathways. GLP-1 can also reduce glucagon secretion from islet α cells and reduce hepatic glucose production.However, both GLP-1 and GIP are rapidly metabolized by DPP-4, resulting in the loss of their insulin-promoting effect.

Iingenelo

Sinemizi-mveliso emininzi ekumgangatho ophezulu enentsebenziswano enzulu, enokubonelela ngeemveliso ezikumgangatho ophezulu kunye namaxabiso akhuphisanayo. Kwaye sinako ukunika izaphulelo zokuthengwa kwezinto ezininzi.Kwaye siyasebenzisana neenkampani ezininzi zokuthunyelwa kwempahla, zinokuzisa iimveliso ngokukhuselekileyo nangokutyibilikayo ezandleni zakho. Ixesha lokuhambisa limalunga neentsuku ezi-3-20 emva kokuqinisekiswa kwentlawulo.

Inkcazo

Into	Test Standard	Testing Result
CBD	Not less than (NLT) 99.5% 99.9%
THC	Not detected	Undetected
Isivavanyi	Method HPLC calculated on the anhydrous basis limit of quotation (LOQ) 0.8ppm
Imbonakalo	Umgubo omhlophe	White powder
Ukuchongwa	In the recorded chromatograms under the determination of the substance, retention time of the main peak of the solution should be consistent with the retention of time of the main peak of the reference solution	Iyahambelana
Indawo yokunyibilika	65~66ºC	65.5ºC
Ilahleko ekomisweni	NMT 1.0%	0.21%
Residual solvents	Ethanol NMT 400ppm Heptane NMT 400ppm	1.92ppm 256.0ppm
Heavy Mental	NMT 20ppm	Iyahambelana
Microbial Limite Test	Method: Plate Counting
Total aerobic bacteria count	NMT 1000cfu/g	Iyahambelana
Combined molds and yeast	NMT 100cfu/g	Iyahambelana
E. Coli	Not detacted per gram	Iyahambelana
Salmanella	Not detacted per 10 gram	Iyahambelana
Conclusion: Conform the testing result is qualified

Ukuthunyelwa kunye nentlawulo

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