Sitagliptin powder

Sitagliptin is an oral antihyperglycemic of the dipeptidyl peptidase-4  inhibitor class. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents for treatment of diabetes mellitus type 2.The benefit of this medicine is its fewer side effects in the control of blood glucose values. While safety is its advantage, efficacy is often challenged as it is often recommended to be combined with other agents such as metformin.

Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that controls blood glucose levels by protecting and enhancing endogenous enteroglycin.Glucose-dependent insulin-releasing peptides (GIP) and glucagon-like peptide-1 (GLP-1) are enteroglycins released in response to dietary intake.

GLP-1 and GIP can increase insulin synthesis and release from islet β cells through intracellular signaling pathways. GLP-1 can also reduce glucagon secretion from islet α cells and reduce hepatic glucose production.However, both GLP-1 and GIP are rapidly metabolized by DPP-4, resulting in the loss of their insulin-promoting effect.

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