I-Reserpine

I-Reserpine iyi-alkaloid ye-indole esetshenziswa ekwelapheni umfutho wegazi ophakeme kanye ne-psychosis. Ekuqaleni yakhishwa esitshalweni i-Serpentine. Kulezi zinsuku, ngenxa yemiphumela engemihle eyengeziwe kanye nemithi emisha engcono emakethe, i-reserpine ayiseyona inketho yokuqala yokwelashwa. I-catecholamines (ama-monoamine neurotransmitters) adlala indima ebalulekile ekulawuleni ukushaya kwenhliziyo, amandla enkontileka ye-myocardial kanye nokumelana ne-peripheral, futhi i-reserpine yenza umphumela wayo wokulwa nomfutho wegazi ophezulu ngokudla ama-catecholamine asuka eziphethweni zemizwa yozwela.

Incibilika ku-chloroform, i-dichloromethane, i-glacial acetic acid, ingancibilika ku-benzene, i-ethyl acetate, inyibilika kancane ku-acetone, i-methanol, i-ethanol, i-ether, i-acetic acid ne-citric acid. Isixazululo se-reserpine siphenduka sibephuzi ngemva kwesikhathi esithile, futhi sibe ne-fluorescence ephawulekayo, futhi i-fluorescence iyathuthukiswa ngemva kokwengezwa kwe-asidi nokuchayeka. I-Reserpine iyisizinda esibuthakathaka. I-Reserpine ingehlisa umfutho wegazi futhi ishaye kancane izinga lokushaya kwenhliziyo. Isenzo saso sihamba kancane, simnene futhi sihlala isikhathi eside. Inomphumela wokupholisa okuhlala isikhathi eside ohlelweni lwezinzwa oluphakathi futhi iyisedative enhle.

I-Reserpine ithinta ngokuyinhloko ukutholwa kwe-norepinephrine kuma-vesicles eziphethweni zezinzwa ezinozwela, okubangela ukuba konakaliswe yi-monoamine oxidase futhi kuqede ukugcinwa kwe-norepinephrine, ngaleyo ndlela kuphazamise ukudluliswa kwemizwa yozwela. Lokhu kubangela ukuvuleka kwemithambo, umfutho wegazi wehle, nokuncipha kwesilinganiso senhliziyo. I-central nervous system sedation kanye nokuvinjelwa kungase kube umphumela we-reserpine engena ebuchosheni futhi iqede indawo yokugcina i-catecholamine. Umphumela we-hypotensive uvela kungakapheli ihora eli-1 ngemuva komjovo we-intravenous. Umphumela we-antihypertensive wokwelashwa ngomlomo uqala cishe isonto eli-1 ngemuva kokuphathwa futhi ufinyelela umphumela wawo omkhulu emavikini angama-2-3 kamuva. Umphumela uphikelela amaviki angu-3-4 ngemva kokuyeka ukwelashwa.

Sinezimboni eziningi zekhwalithi ephezulu ngokubambisana okujulile, ezingakunikeza ngemikhiqizo yekhwalithi ephezulu namanani ancintisanayo. Futhi singanikeza izaphulelo zokuthenga ngobuningi.Futhi sibambisana nezinkampani eziningi ezichwepheshile zokudlulisa impahla, zingaletha imikhiqizo ngokuphepha nangokushelela ezandleni zakho. Isikhathi sokulethwa cishe yizinsuku ezi-3-20 ngemuva kokuqinisekiswa kwenkokhelo.

Ukusebenzisana kwezidakamizwa
Izinzwa ezijwayelekile zingathuthukisa umphumela we-antihypertensive we-reserpine. Ngokuhambisana ne-ethanol noma i-central nervous system inhibitors, umphumela ovimbelayo omaphakathi ungabhebhetheka.
1. kuhlanganiswe nezinye izidakamizwa ze-antihypertensive noma i-diuretics kungaqinisa umphumela we-antihypertensive, umthamo udinga ukulungiswa; Ngokuhlanganiswa ne-β-blocker, umphumela wokugcina ungathuthukiswa;
2. kuhlanganiswe ne-digitalis noma i-quinidine, imithamo emikhulu ingabangela i-arrhythmia;
3. kuhlanganiswe ne-levodopa kungabangela ukuncipha kwe-dopamine, okuholela esifweni sikaParkinson;
4. kuhlanganiswe nezidakamizwa ze-adrenergic ezingaqondile njenge-ephedrine, amphetamine, njll., kungenza ukugcinwa kwe-catecholamine kunciphe, kuvimbele umphumela wezidakamizwa ze-adrenergic;
5. kuhlanganiswe nezidakamizwa eziqondile ze-adrenergic ezifana ne-epinephrine, isoproterenol, norepinephrine, i-mehydroxyamine, i-deoxyadrenalin, njll., ingandisa umphumela wayo;
6. kuhlanganiswe ne-tricyclic antidepressants, imiphumela ye-reserpine ne-antidepressants yaba buthaka;
7. ama-barbiturates angaqinisa umphumela wokulalisa omaphakathi we-reserpine.

Ukweqisa kwezidakamizwa
I-Reserpine ayinayo i-antidote ethile, ayikwazi ukuqedwa nge-dialysis, izinyathelo zokwelapha ziyizimpawu zokwelashwa ezisekelayo. I-overdose ibangela ukucindezeleka kokuphefumula, i-coma, umfutho wegazi ophansi, ukudlikizela, kanye ne-hypothermia. Kuleli qophelo, i-gastric lavage kufanele ithathwe ukuze kubangele ukuhlanza, ngisho nangemva kwamahora ambalwa emithi. Iziguli ezine-hypotension ezinzima zafakwa endaweni yokulala, izinyawo zabo zaphakanyiswa, futhi izidakamizwa eziqondile ze-epinephrine zazilawulwa ngokucophelela ukuze kukhuliswe umfutho wegazi. Ukuhogela umoya-mpilo nokuphefumula okwenziwa kwanikezwa iziguli ezinokucindezeleka kokuphefumula. Izidakamizwa ze-Anticholinergic zelapha izimpawu zesisu; Futhi ukulungisa ukuphelelwa amanzi emzimbeni, ukungalingani kwe-electrolyte, i-hepatic coma, ne-hypotension. Iziguli kufanele ziqashelwe okungenani amahora angama-72 ngoba isenzo se-reserpine sihlala isikhathi eside. Umfutho wegazi ufike ezingeni eligculisayo.

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