Reserpine

I-Reserpine i-alkaloid ye-indole esetyenziswa kunyango lwe-hypertension kunye ne-psychosis. Ekuqaleni yakhutshwa kwisityalo iSerpentine. Kule mihla, ngenxa yeziphumo ebezingalindelekanga ezininzi kunye namachiza amatsha angcono kwimarike, i-reserpine ayiselulo khetho lokuqala lonyango. I-catecholamines (i-monoamine neurotransmitters) idlala indima ebalulekileyo ekulawuleni izinga lokubetha kwentliziyo, amandla ekhontrakthi ye-myocardial kunye nokumelana ne-peripheral, kwaye i-reserpine yenza i-antihypertensive effect ngokutya i-catecholamines kwi-peripheral sympathetic nerve endings.

I-Soluble kwi-chloroform, i-dichloromethane, i-acetic acid ye-glacial, inokunyibilika kwi-benzene, i-ethyl acetate, i-soluble kancinane kwi-acetone, i-methanol, i-ethanol, i-ether, i-acetic acid kunye ne-citric acid solutions. Isisombululo se-reserpine sijika sibe tyheli emva kwexesha elithile, kwaye sine-fluorescence ebalulekileyo, kwaye i-fluorescence iphuculwe emva kokudibanisa ne-asidi kunye nokuvezwa. I-Reserpine sisiseko esibuthathaka. I-Reserpine inokwehlisa uxinzelelo lwegazi kunye nokucotha kwentliziyo. Isenzo sayo siyacotha, sithambile kwaye sihlala ixesha elide. Inefuthe elihlala ixesha elide lokuthomalalisa kwinkqubo ye-nervous central kwaye i-sedative efanelekileyo.

I-Reserpine ichaphazela ngokuyinhloko ukunyuswa kwe-norepinephrine kwii-vesicles kwi-nerve endings endings, ebangela ukuba ithotywe yi-monoamine oxidase kunye nokunciphisa ukugcinwa kwe-norepinephrine, ngaloo ndlela iphazamise ukuhanjiswa kweempembelelo ze-nerve sympathetic. Oku kubangela ukuvuleka kwe-vascular, ukunciphisa uxinzelelo lwegazi, kunye nokunciphisa izinga lentliziyo. Inkqubo ye-nervous sedation kunye nokuvinjelwa kunokuba ngumphumo we-reserpine engena kwingqondo kunye nokunciphisa ukugcinwa kwe-catecholamine ephakathi. Isiphumo se-hypotensive sibonakala kwiyure enye emva kwesitofu se-intravenous. Impembelelo ye-antihypertensive yonyango lomlomo iqala malunga neveki ye-1 emva kokulawulwa kwaye ifikelele kwisiphumo sayo esiphezulu kwiiveki ezi-2-3 kamva. Isiphumo siqhubeka kwiiveki ezi-3-4 emva kokuyeka unyango.

Sinemizi-mveliso emininzi ekumgangatho ophezulu enentsebenziswano enzulu, enokubonelela ngeemveliso ezikumgangatho ophezulu kunye namaxabiso akhuphisanayo. Kwaye sinako ukunika izaphulelo zokuthengwa kwezinto ezininzi.Kwaye siyasebenzisana neenkampani ezininzi zokuthunyelwa kwempahla, zinokuzisa iimveliso ngokukhuselekileyo nangokutyibilikayo ezandleni zakho. Ixesha lokuhambisa limalunga neentsuku ezi-3-20 emva kokuqinisekiswa kwentlawulo.

Ukusebenzisana kweziyobisi
I-anesthetics jikelele inokunyusa impembelelo ye-antihypertensive ye-reserpine. Ngokudibanisa ne-ethanol okanye i-central nervous system inhibitors, i-central inhibitory effect inokuba nzima.
1. idibaniswe namanye amachiza e-antihypertensive okanye i-diuretics inokomeleza umphumo we-antihypertensive, umthamo kufuneka ulungelelaniswe; Ngokudibanisa ne-β-blocker, umphumo wokugqibela unokuphuculwa;
2. idibaniswe ne-digitalis okanye i-quinidine, amanani amakhulu angabangela i-arrhythmia;
3. idibene ne-levodopa inokubangela ukuchithwa kwe-dopamine, ekhokelela kwisifo sika-Parkinson;
4. kudityaniswe neziyobisi ezingangqalanga ze-adrenergic ezifana ne-ephedrine, i-amphetamine, njl., zingenza ukugcinwa kwe-catecholamine kuphelelwe, kuthintele umphumo weziyobisi ze-adrenergic;
5. kudityaniswe neziyobisi ezithe ngqo ze-adrenergic ezifana ne-epinephrine, isoproterenol, norepinephrine, mehydroxyamine, deoxyadrenalin, njl., inokwandisa umphumo wayo;
6. idibaniswe ne-tricyclic antidepressants, imiphumo ye-reserpine kunye ne-antidepressants yayibuthathaka;
7. i-barbiturates inokomeleza i-central sedative effect ye-reserpine.

Ukugqithiswa kweziyobisi
I-Reserpine ayinayo i-antidote ethile, ayikwazi ukupheliswa nge-dialysis, amanyathelo onyango ayimpawu kunye nonyango oluxhasayo. Ukugqithisa ngokweqile kubangela ukudakumba kokuphefumla, isiqaqa, uxinzelelo lwegazi oluphantsi, ukuxhuzula, kunye ne-hypothermia. Ngeli xesha, i-gastric lavage kufuneka ithathwe ukubangela ukugabha, nasemva kweeyure ezininzi zokusetyenziswa iyeza. Izigulane ezine-hypotension ezinzima zibekwe kwindawo yokulala, iinyawo zabo ziphakanyiswe, kwaye iziyobisi ze-epinephrine ezithe ngqo zilawulwa ngokucophelela ukunyusa uxinzelelo lwegazi. Ukuphefumla ioksijini kunye nokuphefumla okwenziweyo kwanikwa izigulane ezinoxinzelelo lokuphefumla. Amachiza e-Anticholinergic aphatha iimpawu zesisu; Kwaye ngokuchanekileyo ukungabikho kwamanzi emzimbeni, ukungalingani kwe-electrolyte, i-hepatic coma, kunye ne-hypotension. Izigulane kufuneka ziqwalaselwe ubuncinane iiyure ezingama-72 kuba isenzo se-reserpine sihlala ixesha elide. Uxinzelelo lwegazi ukuya kwinqanaba elanelisayo.

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