Reserpine

Reserpine bụ alkaloid indole nke a na-eji na ọgwụgwọ ọbara mgbali elu na psychosis. E sitere na osisi Serpentine nweta na mbụ. N'oge a, n'ihi mmetụta ndị ọzọ na ọgwụ ọhụrụ ka mma na ahịa, reserpine abụghịzi nhọrọ mbụ maka ọgwụgwọ. Catecholamines (monoamine neurotransmitters) na-arụ ọrụ dị mkpa na nhazi nke ọnụọgụ obi, ike myocardial contractile na nguzogide mpụta, na reserpine na-egosipụta mmetụta antihypertensive ya site na iri catecholamines site na njedebe akwara ọmịiko.

Soluble na chloroform, dichloromethane, glacial acetic acid, nwere ike igbari na benzene, ethyl acetate, ubé soluble na acetone, methanol, ethanol, ether, acetic acid na citric acid ngwọta. Ngwọta nke reserpine na-atụgharị odo mgbe oge ụfọdụ gasịrị, ma nwee mmetụta dị ịrịba ama, na fluorescence na-eme ka ọ dịkwuo mma mgbe mgbakwunye acid na ikpughe. Reserpine bụ isi adịghị ike. Reserpine nwere ike ibelata ọbara mgbali ma jiri nwayọ nwayọ nwayọ. Omume ya na-adị nwayọọ, dị nro ma na-adịte aka. Ọ na-enwe mmetụta dị jụụ na-adịte aka na usoro nhụjuanya nke etiti ma bụrụ ezigbo ogwuura.

Reserpine bụ isi na-emetụta nnabata nke norepinephrine n'ime vesicles na njedebe akwara ọmịiko, na-eme ka ọ ghara imebi ya site na monoamine oxidase na imebi nchekwa nke norepinephrine, si otú a na-emebi nnyefe nke mkpali akwara ọmịiko. Nke a na-ebute mgbasa nke vaskụla, mbelata ọbara mgbali, na mbelata ọnụọgụ obi. Usoro nkwụsịtụ na mgbochi nke etiti ahụ nwere ike ịbụ nsonaazụ reserpine na-abanye n'ụbụrụ ma mebie ebe nchekwa catecholamine nke etiti. Mmetụta hypotensive na-apụta n'ime awa 1 mgbe ịgba ọgwụ mgbochi ahụ gasịrị. Mmetụta antihypertensive nke ọgwụgwọ ọnụ na-amalite ihe dịka otu izu mgbe nchịkwa gasịrị wee rute mmetụta kachasị elu mgbe izu 2-3 gachara. Mmetụta na-adịgide adịgide maka izu 3-4 mgbe ịkwụsị ọgwụgwọ.

Anyị nwere ọtụtụ ụlọ ọrụ dị elu nke nwere nkwado miri emi, nke nwere ike inye gị ngwaahịa dị elu na ọnụ ahịa asọmpi. Anyị nwekwara ike inye ego maka nnukwu ịzụrụ ihe. Anyị na-akwado ọtụtụ ụlọ ọrụ na-ebuga ibu ndị ọkachamara, nwere ike ịnapụta ngwaahịa n'enweghị nsogbu na aka gị. Oge nnyefe bụ ihe dịka ụbọchị 3-20 mgbe nkwenye nke ịkwụ ụgwọ gasịrị.

Mmekọrịta ọgwụ
Ọgwụ anestetiiki izugbe nwere ike ịkwalite mmetụta antihypertensive nke reserpine. Na mgbakwunye na ethanol ma ọ bụ ndị na-egbochi usoro nhụjuanya nke etiti, enwere ike ime ka mmetụta nke etiti ahụ dịkwuo njọ.
1. jikọtara ya na ọgwụ ndị ọzọ antihypertensive ma ọ bụ diuretics nwere ike ime ka mmetụta antihypertensive sie ike, ọ dị mkpa ka edozi dose ahụ; Na mgbakwunye na β-blocker, enwere ike ịkwalite mmetụta ikpeazụ;
2. jikọtara ya na digitalis ma ọ bụ quinidine, nnukwu doses nwere ike ime ka arrhythmia;
3. jikọtara ya na levodopa nwere ike ime ka dopamine depletion, na-eduga na ọrịa Parkinson;
4. jikọtara ya na ọgwụ adrenergic na-apụtaghị ìhè dị ka ephedrine, amphetamine, wdg, nwere ike ime ka nchekwa catecholamine kwụsị, gbochie mmetụta nke ọgwụ adrenergic;
5. jikọtara ya na ọgwụ adrenergic kpọmkwem dị ka epinephrine, isoproterenol, norepinephrine, mehydroxyamine, deoxyadrenalin, wdg, nwere ike ịgbatị mmetụta ya;
6. jikọtara ya na tricyclic antidepressants, mmetụta nke reserpine na antidepressants na-ebelata;
7. Barbiturates nwere ike iwusi mmetụta nchịkwa nke etiti nke reserpine.

Ịṅụbiga mmanya ókè
Reserpine enweghị ọgwụ mgbochi akọwapụtara, enweghị ike iwepụ ya site na dialysis, usoro ọgwụgwọ bụ ihe mgbaàmà na ọgwụgwọ nkwado. Ịṅụbiga mmanya ókè na-akpata ịda mbà n'obi nke iku ume, coma, ọbara mgbali elu, mgbakasị ahụ, na hypothermia. N'oge a, a ga-ewere ịsacha gastric iji mee ka agbọ agbọ, ọbụlagodi mgbe ọtụtụ awa gasịrị ọgwụ. A na-etinye ndị ọrịa nwere nnukwu hypotension n'ọnọdụ ụgha, a na-ebuli ụkwụ ha elu, a na-ejikwa nlezianya na-elekọta ọgwụ epinephrine kpọmkwem iji kwalite ọbara mgbali elu. E nyere ndị ọrịa nwere nkụda mmụọ iku ume ikuku oxygen na iku ume artificial. Ọgwụ anticholinergic na-agwọ mgbaàmà eriri afọ; Na akpịrị ịkpọ nkụ ziri ezi, ahaghị nhata electrolyte, coma imeju, na hypotension. Ekwesịrị ịhụ ndị ọrịa ma ọ dịkarịa ala awa 72 n'ihi na ọrụ reserpine na-adịru ogologo oge. Ọbara mgbali elu ka afọ ojuju.

1. Ị bụ ụlọ ọrụ mmepụta ihe ma ọ bụ ụlọ ọrụ ịzụ ahịa?
Anyị bụ ụlọ ọrụ na-ejikọta ụlọ ọrụ na ịzụ ahịa, na-enye ọrụ nkwụsịtụ.OEM nwere ike ịnakwere.

2. Ị na-enye samples? Ọ bụ n'efu ka ọ bụ mgbakwunye?
Free samples. The sample si ibu ego kwesịrị ịkwụ ụgwọ gị n'akụkụ.

3. Ị nwere asambodo ọ bụla metụtara njikwa mma?
ISO 9001: 2008 asambodo iji hụ na ịdị mma.

4. Kedu ihe m ga-enye ka m nweta nhota okwu?
Pls na-agwa anyị ụdị ngwaahịa nke ị chọrọ, iji ọnụ ọgụgụ, adreesị na ihe ndị a chọrọ. A ga-edepụta nkwupụta maka ntinye aka gị n'oge.

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Asụsụ Asụsụ: Bekee.