Reserpine

Reserpine ke alkaloid ea indole e sebelisoang ho phekola khatello ea mali le psychosis. Qalong e ne e ntšitsoe semeleng sa Serpentine. Matsatsing ana, ka lebaka la litla-morao tse ngata le lithethefatsi tse ncha tse betere 'marakeng, reserpine ha e sa le khetho ea pele ea kalafo. Li-catecholamine (li-monoamine neurotransmitters) li phetha karolo ea bohlokoa taolong ea ho otla ha pelo, matla a contractile a myocardial le peripheral resistance, 'me reserpine e fana ka phello ea eona ea antihypertensive ka ho ja li-catecholamine tse tsoang methapong ea methapo ea kutlo.

E qhibiliha ka chloroform, dichloromethane, glacial acetic acid, e ka qhibiliha ka benzene, ethyl acetate, e qhibilihang hanyenyane ka har'a acetone, methanol, ethanol, ether, acetic acid le citric acid solution. Tharollo ea reserpine e fetoha mosehla ka mor'a nako e itseng, 'me e na le fluorescence e kholo,' me fluorescence e ntlafatsoa ka mor'a ho eketsoa ha asiti le ho pepeseha. Reserpine ke setsi se fokolang. Reserpine e ka theola khatello ea mali le ho fokotsa lebelo la pelo. Ketso ea eona e lieha, e bonolo ebile e tšoarella nako e telele. E na le phello e khutsitseng ea nako e telele tsamaisong ea methapo e bohareng 'me e na le sedative e ntle.

Reserpine e ama haholo-holo ho kenngoa ha norepinephrine ka har'a li-vesicles ho lipheletsong tsa methapo e nang le kutloelo-bohloko, ho etsa hore e senyehe ke monoamine oxidase le ho senya polokelo ea norepinephrine, kahoo e sitise phetiso ea methapo ea kutlo ea kutlo. Sena se fella ka ho atoloha ha methapo ea mali, khatello ea mali e fokotsehile, 'me lebelo la pelo le fokotsehile. The central nervous system sedation le inhibition e ka 'na ea e-ba phello ea reserpine e kenang bokong le ho senya polokelo ea catecholamine e bohareng. Phello ea hypotensive e bonahala nakong ea hora e le 'ngoe ka mor'a ente ea methapo. Phello ea antihypertensive ea kalafo ea molomo e qala hoo e ka bang beke e le 1 ka mor'a ts'ebeliso mme e fihla sehlohlolong sa eona kamora libeke tse 2-3. Phello e tsoela pele bakeng sa libeke tse 3-4 ka mor'a ho khaotsa phekolo.

Re na le lifeme tse ngata tsa boleng bo holimo tse nang le tšebelisano e tebileng, tse ka u fang lihlahisoa tsa boleng bo holimo le litheko tsa tlholisano. Hape re ka fana ka litheolelo bakeng sa ho reka ka bongata.'Me re sebelisana le lik'hamphani tse ngata tsa litsebi tse tsamaisang thepa, li ka isa lihlahisoa ka mokhoa o sireletsehileng le ka thelelo matsohong a hau. Nako ea ho fana e ka ba matsatsi a 3-20 ka mor'a hore ho netefatsoe tefo.

Tšebelisano ea lithethefatsi
Lithethefatsi tse akaretsang li ka ntlafatsa phello ea antihypertensive ea reserpine. Ha e kopantsoe le ethanol kapa li-inhibitors tsa methapo ea bohareng, phello e thibelang e ka mpefala.
1. ho kopantsoe le lithethefatsi tse ling tsa antihypertensive kapa diuretics ho ka matlafatsa phello ea antihypertensive, lethal dose le hloka ho fetoloa; Ha e kopantsoe le β-blocker, phello ea ho qetela e ka ntlafatsoa;
2. ho kopantsoe le digitalis kapa quinidine, tekanyo e kholo e ka baka arrhythmia;
3. ho kopantsoe le levodopa ho ka etsa hore dopamine e fokotsehe, e lebisang ho lefu la Parkinson;
4. ho kopantsoe le lithethefatsi tse sa tobang tsa adrenergic tse kang ephedrine, amphetamine, joalo-joalo, li ka etsa hore polokelo ea catecholamine e fokotsehe, e thibela phello ea lithethefatsi tsa adrenergic;
5. ho kopantsoe le lithethefatsi tse tobileng tsa adrenergic tse kang epinephrine, isoproterenol, norepinephrine, mehydroxyamine, deoxyadrenalin, joalo-joalo, e ka lelefatsa phello ea eona;
6. ho kopantsoe le li-anti-depressants tsa tricyclic, liphello tsa reserpine le li-anti-depressants li fokotsehile;
7. li-barbiturates li ka matlafatsa phello e bohareng ea sedative ea reserpine.

Tšebeliso e feteletseng ea lithethefatsi
Reserpine ha e na antidote e khethehileng, e ke ke ea felisoa ka dialysis, mehato ea phekolo ke matšoao le phekolo e tšehetsang. Tšebeliso e feteletseng ea lithethefatsi e baka khatello ea maikutlo, koma, khatello e tlase ea mali, khatello ea maikutlo le hypothermia. Mothating ona, ho hlatsuoa ka mpeng ho tlameha ho nkuoa ho etsa hore motho a hlatse, le ka mor'a lihora tse 'maloa tsa meriana. Bakuli ba nang le hypotension e matla ba ile ba behoa sebakeng sa leshano, maoto a bona a phahamisoa, 'me lithethefatsi tse tobileng tsa epinephrine li ne li tsamaisoa ka hloko ho matlafatsa khatello ea mali. Ho hema oksijene le phefumoloho ea maiketsetso li ile tsa fuoa bakuli ba nang le khatello ea maikutlo ea ho hema. Lithethefatsi tsa anticholinergic li phekola matšoao a mala; 'Me ho lokisa dehydration, electrolyte imbalance, hepatic coma, le hypotension. Bakuli ba lokela ho shejoa bonyane lihora tse 72, hobane ts'ebetso ea reserpine e nka nako e telele. Khatello ea mali ho ea boemong bo khotsofatsang.

1. Na u feme kapa k'hamphani ea khoebo?
Re komnay e kopanyang indasteri le khoebo, ho fana ka ts'ebeletso e le 'ngoe.OEM e ka amoheloa.

2. O fana ka mehlala? Na ke mahala kapa ho feta?
Mehlala ea mahala. Tefiso ea thepa ea sampole e hloka ho lefuoa ka lehlakore la hau.

3. O na le litifikeiti tse amanang le taolo ea boleng?
Setifikeiti sa ISO 9001:2008 ho netefatsa boleng.

4. Ke fane ka eng ho fumana khotheishene?
Pls re tsebise ka mofuta oa sehlahisoa seo u se hlokang, bongata ba odara, aterese le litlhoko tse ikhethileng. Khotheishene e tla etsoa bakeng sa referense ea hau ka nako.

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