Sotalol hydrochloride

Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC₅₀s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).

Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.

Anyị nwere ọtụtụ ụlọ ọrụ dị elu nke nwere nkwado miri emi, nke nwere ike inye gị ngwaahịa dị elu na ọnụ ahịa asọmpi. Anyị nwekwara ike inye ego maka nnukwu ịzụrụ ihe. Anyị na-akwado ọtụtụ ụlọ ọrụ na-ebuga ibu ndị ọkachamara, nwere ike ịnapụta ngwaahịa n'enweghị nsogbu na aka gị. Oge nnyefe bụ ihe dịka ụbọchị 3-20 mgbe nkwenye nke ịkwụ ụgwọ gasịrị.

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