Sotalol hydrochloride

99% Raw Material Sotalol hydrochloride Pharmaceutical Powder CAS 959-24-0

Orukọ ọja:
Sotalol hydrochloride
Ipele:
Pharmaceutical grade
Awọn ohun-ini:
white powder/flake
Iṣakojọpọ:
25kg / ilu
MOQ:
1 kilo
Ibi ipamọ:Itura Gbẹ Ibi
Igbesi aye ipamọ:ọdun meji 2

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Awọn alaye

Awọn afi

Apejuwe ọja

Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC₅₀s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).

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Ohun elo

Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.

Awọn anfani

A ni ọpọlọpọ awọn ile-iṣelọpọ giga-giga pẹlu ifowosowopo jinlẹ, eyiti o le fun ọ ni awọn ọja to gaju ati awọn idiyele ifigagbaga. Ati pe a tun le fun awọn ẹdinwo fun awọn rira olopobobo.Ati pe a ṣe ifọwọsowọpọ pẹlu ọpọlọpọ awọn ile-iṣẹ gbigbe ẹru ẹru ọjọgbọn, le fi awọn ọja ranṣẹ lailewu ati laisiyonu si ọwọ rẹ. Akoko ifijiṣẹ jẹ nipa awọn ọjọ 3-20 lẹhin ijẹrisi isanwo.

Sipesifikesonu

Items	Standards	Results
Ifarahan	White or off-white solid powder	Ibamu
Identification	By IR	Ibamu
	By HPLC	Ibamu
Solubility	Soluble in DMF, sparingly soluble in THF,insoluble in water	Ibamu
Polymorphic Form	Polymorphic form 1	Ibamu
Ojuami Iyo	211ºC~216ºC	212.8ºC~214.9ºC
Water Content	≤ 0.50%	0.10%
Heavy Metals	≤ 20ppm	Ibamu
Residue on Ignition	≤ 0.20%	0.09%
Related Substance	Any single impurity: ≤0.10%	0.06%
	Total Impurities: ≤1.00%	0.16%
Ayẹwo (on the anhydrous basis)	98.0%~102.0%	99.94%
Particle Size	D90: ≤100µm	Ibamu
Reference Standard	In-house Standard

Sowo ati owo sisan

<trp-post-container data-trp-post-id='14022'>Sotalol hydrochloride</trp-post-container>

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