Sotalol hydrochloride

99% Raw Material Sotalol hydrochloride Pharmaceutical Powder CAS 959-24-0

Önümiň ady:
Sotalol hydrochloride
Baha:
Pharmaceutical grade
Aýratynlyklary:
white powder/flake
Gaplamak:
25 kg / deprek
MOQ:
1 kilo
Saklama:Gurak ýer
Ýaramlylyk möhleti:2 ýyl

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Jikme-jiklikler

Bellikler

Önümiň beýany

Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC₅₀s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).

Arza

Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.

Üstünlikleri

Çuňňur hyzmatdaşlygy bolan ýokary hilli önümler we bäsdeşlik bahalary bilen üpjün edip biljek köp sanly ýokary hilli zawodlarymyz bar. Şeýle hem, köpçülikleýin satyn almak üçin arzanladyş berip bileris. Köp hünärli ýük ekspeditor kompaniýalary bilen hyzmatdaşlyk edýäris, önümleri ygtybarly we rahat eliňize berip bileris. Eltip beriş wagty, töleg tassyklanandan 3-20 gün soň.

Spesifikasiýa

Items	Standards	Results
Daş görnüşi	White or off-white solid powder	Jogap berýär
Identification	By IR	Jogap berýär
	By HPLC	Jogap berýär
Solubility	Soluble in DMF, sparingly soluble in THF,insoluble in water	Jogap berýär
Polymorphic Form	Polymorphic form 1	Jogap berýär
Eriş nokady	211ºC~216ºC	212.8ºC~214.9ºC
Water Content	≤ 0.50%	0.10%
Heavy Metals	≤ 20ppm	Jogap berýär
Residue on Ignition	≤ 0.20%	0.09%
Related Substance	Any single impurity: ≤0.10%	0.06%
	Total Impurities: ≤1.00%	0.16%
Derňew (on the anhydrous basis)	98.0%~102.0%	99.94%
Particle Size	D90: ≤100µm	Jogap berýär
Reference Standard	In-house Standard

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Sorag-jogap

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