Sotalol hydrochloride

99% Raw Material Sotalol hydrochloride Pharmaceutical Powder CAS 959-24-0

Igama lomkhiqizo:
Sotalol hydrochloride
Ibanga:
Pharmaceutical grade
Izakhiwo:
white powder/flake
Ukupakisha:
25kg/isigubhu
I-MOQ:
1 kilo
Isitoreji:Indawo Eyomile Epholile
Impilo yeshelufu:iminyaka engu-2

XHUMANA MANJE PDF KHIPHA

Imininingwane

Omaka

Incazelo Yomkhiqizo

Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC₅₀s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).

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Isicelo

Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.

Izinzuzo

Sinezimboni eziningi zekhwalithi ephezulu ngokubambisana okujulile, ezingakunikeza ngemikhiqizo yekhwalithi ephezulu namanani ancintisanayo. Futhi singanikeza izaphulelo zokuthenga ngobuningi.Futhi sibambisana nezinkampani eziningi ezichwepheshile zokudlulisa impahla, zingaletha imikhiqizo ngokuphepha nangokushelela ezandleni zakho. Isikhathi sokulethwa cishe yizinsuku ezi-3-20 ngemuva kokuqinisekiswa kwenkokhelo.

Ukucaciswa

Items	Standards	Results
Ukubukeka	White or off-white solid powder	Iyahambisana
Identification	By IR	Iyahambisana
	By HPLC	Iyahambisana
Solubility	Soluble in DMF, sparingly soluble in THF,insoluble in water	Iyahambisana
Polymorphic Form	Polymorphic form 1	Iyahambisana
I-Melting Point	211ºC~216ºC	212.8ºC~214.9ºC
Water Content	≤ 0.50%	0.10%
Heavy Metals	≤ 20ppm	Iyahambisana
Residue on Ignition	≤ 0.20%	0.09%
Related Substance	Any single impurity: ≤0.10%	0.06%
	Total Impurities: ≤1.00%	0.16%
Isivivinyo (on the anhydrous basis)	98.0%~102.0%	99.94%
Particle Size	D90: ≤100µm	Iyahambisana
Reference Standard	In-house Standard

Ukuthumela nokukhokha

<trp-post-container data-trp-post-id='14022'>Sotalol hydrochloride</trp-post-container>

FAQ

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