Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.
Me gelek kargehên kalîteya bilind bi hevkariyek kûr heye, ku dikarin ji we re hilberên kalîteya bilind û bihayên reqabetê peyda bikin. Û em dikarin ji bo kirînên mezin erzanan jî bidin. Û em bi gelek pargîdaniyên barkêş ên profesyonel re hevkariyê dikin, dikarin hilberan bi ewlehî û bi aramî radestî destên we bikin. Dema radestkirinê piştî pejirandina dravdanê 3-20 rojan e.
Items | Standards | Results | |
Xuyabûnî | White or off-white solid powder | Lihev dike | |
Identification | By IR | Lihev dike | |
By HPLC | Lihev dike | ||
Solubility | Soluble in DMF, sparingly soluble in THF,insoluble in water | Lihev dike | |
Polymorphic Form | Polymorphic form 1 | Lihev dike | |
Melting Point | 211ºC~216ºC | 212.8ºC~214.9ºC | |
Water Content | ≤ 0.50% | 0.10% | |
Heavy Metals | ≤ 20ppm | Lihev dike | |
Residue on Ignition | ≤ 0.20% | 0.09% | |
Related Substance | Any single impurity: ≤0.10% | 0.06% | |
Total Impurities: ≤1.00% | 0.16% | ||
Assay (on the anhydrous basis) | 98.0%~102.0% | 99.94% | |
Particle Size | D90: ≤100µm | Lihev dike | |
Reference Standard | In-house Standard |
1. Ma hûn kargehek an pargîdaniyek bazirganî ne?
Em pargîdaniyek in ku pîşesazî û bazirganiyê entegre dike, karûbarê yek-stop peyda dike. OEM dikare were pejirandin.
2. Ma hûn nimûne pêşkêş dikin? Ew belaş an zêde ye?
Nimûneyên belaş. Pêdivî ye ku heqê barkirina nimûneyê ji hêla we ve were dayîn.
3. Hûn belgeyên ku bi kontrola kalîteyê ve girêdayî ne?
Sertîfîkaya ISO 9001: 2008 ji bo misogerkirina kalîteyê.
4. Divê ez çi peyda bikim da ku jêderkek bistînim?
Ji kerema xwe celebê hilberê ku hûn hewce ne, hêjmara fermanê, navnîşan û hewcedariyên taybetî me agahdar bikin. Dê di wextê de ji bo referansa we veqetandin were çêkirin.
5. Hûn rêbazek dravdanê çawa tercîh dikin? Mercên çawa têne qebûl kirin?
Mercên Radestkirina Pejirandî: FOB, CFR, CIF, EXW;
Accepted Payment Currency:USD;EUR
Tîpa dravdana pejirandî: T/T, Yekîtiya Rojavayî; Paypal, Ewlekariya Bazirganî.
Zimanê axaftinê: Îngilîzî.
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