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Sotalol hydrochloride
Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.
Nou gen anpil faktori-wo kalite ak gwo koperasyon, ki ka ba ou bon jan kalite pwodwi ak pri konpetitif. Epi nou ka bay tou rabè pou acha esansyèl. Epi nou kolabore ak anpil konpayi transpò machandiz pwofesyonèl, ka delivre pwodwi san danje epi san pwoblèm nan men ou. Tan livrezon se sou 3-20 jou apre konfimasyon peman an.
| Items | Standards | Results | |
| Aparans | White or off-white solid powder | Konfòme | |
| Identification | By IR | Konfòme | |
| By HPLC | Konfòme | ||
| Solubility | Soluble in DMF, sparingly soluble in THF,insoluble in water | Konfòme | |
| Polymorphic Form | Polymorphic form 1 | Konfòme | |
| Pwen k ap fonn | 211ºC~216ºC | 212.8ºC~214.9ºC | |
| Water Content | ≤ 0.50% | 0.10% | |
| Heavy Metals | ≤ 20ppm | Konfòme | |
| Residue on Ignition | ≤ 0.20% | 0.09% | |
| Related Substance | Any single impurity: ≤0.10% | 0.06% | |
| Total Impurities: ≤1.00% | 0.16% | ||
| Esè (on the anhydrous basis) | 98.0%~102.0% | 99.94% | |
| Particle Size | D90: ≤100µm | Konfòme | |
| Reference Standard | In-house Standard | ||
1. Èske ou se yon faktori oswa yon konpayi komès?
Nou se yon konpayi entegre endistri ak komès, bay yon sèl-stop service.OEM ta ka aksepte.
2. ou bay echantiyon yo genyen? Èske li gratis oswa siplemantè?
Echantiyon gratis. Frè machandiz echantiyon an bezwen peye bò kote ou.
3. Èske ou gen nenpòt sètifika ki gen rapò ak kontwòl kalite?
ISO 9001:2008 sètifikasyon asire bon jan kalite.
4. Kisa mwen ta dwe bay pou jwenn yon sitasyon?
Pls enfòme nou sou kalite pwodwi ou bezwen, kantite lòd, adrès ak kondisyon espesifik yo.Y ap fè sitasyon an pou referans ou nan tan.
5. Ki kalite metòd peman ou pito? Ki kalite kondisyon yo aksepte?
Kondisyon livrezon yo aksepte: FOB, CFR, CIF, EXW;
Accepted Payment Currency:USD;EUR
Kalite Peman Aksepte: T/T, Western Union; Paypal, asirans komès.
Lang pale: Angle.
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