Sirolimus Rapamycin Powder

Pharmaceutical Grade Pure 99% Sirolimus Rapamycin Powder CAS 53123-88-9

產品名稱：
Sirolimus Rapamycin Powder
年級：
Pharmaceutical grade
特性：
白色粉末
包裝：
25公斤/桶
最小起訂量：
1 kilo
貯存：陰涼乾燥處
保存期限：2年

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產品描述

Rapamycin is produced by the soil bacterium Streptomyces hygroscopicus. The drug's name comes from Rapa Nui, the indigenous name of Easter Island, where the compound was originally discovered in soil samples in the 1970s.

Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.

應用

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.

Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

優點

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規格

ITEM	規格	RESULT	METHOD
外貌	White powder, neutral odor, highly hygroscopic	符合	Visual
鑑別	Standard solution and test solution same spot,RF	符合	TLC
Specific Optical	-2.4°~ -2.8°	-2.72°
Heavy metals (as PB)	≤10ppm	符合	AAS
Sulfate (SO4)	≤0.02%	符合	Colorimetry
Chloride (Cl)	≤0.02%	符合	Colorimetry
Phosphate Ion (P)	≤5ppm	符合	Colorimetry
Residual solvent(ethanol)	≤1.0%	符合	HS-GC
pH	4.5~7.0	5.10
Related substance	Spot not bigger than standard solution spot	No spot	TLC
Water Content	≤2%	0.26%	KF
Assay (dried basis)	98.0%--102.0%	99.48%	Potentiometric titration
Assay (dried basis)	98.5%--100%	99.2%	HPLC