Sirolimus Rapamycin Powder

Pharmaceutical Grade Pure 99% Sirolimus Rapamycin Powder CAS 53123-88-9

Product nomen:
Sirolimus Rapamycin Powder
Gradus:
Pharmaceutical grade
Possessiones:
cerussa
Stipare:
25kg/orum
MOQ:
1 kilo
Repono:Frigus siccum
Fasciae vita:Annis II

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depictio producti

Rapamycin is produced by the soil bacterium Streptomyces hygroscopicus. The drug's name comes from Rapa Nui, the indigenous name of Easter Island, where the compound was originally discovered in soil samples in the 1970s.

Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.

Applicationem

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.

Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

commoda

Multas officinas summus qualitas habemus cum magna cooperatione, quae vobis praebere potest magnas qualitates productorum et pretia competitive. Etiam infringo pro mole emptionibus dare possumus. Et nos cooperamur cum multis onerariis professionalibus societatibus transmissis, fructus tuto ac blande manibus tuis tradere possumus. Partus tempus est circiter 3-20 dies post confirmationem solutionis.

Specification

ITEM	SPECIFICATION	RESULT	METHOD
Aspectus	White powder, neutral odor, highly hygroscopic	Conforms	Visual
Lepidium sativum	Standard solution and test solution same spot,RF	Conforms	TLC
Specific Optical	-2.4°~ -2.8°	-2.72°
Heavy metals (as PB)	≤10ppm	Conforms	AAS
Sulfate (SO4)	≤0.02%	Conforms	Colorimetry
Chloride (Cl)	≤0.02%	Conforms	Colorimetry
Phosphate Ion (P)	≤5ppm	Conforms	Colorimetry
Residual solvent(ethanol)	≤1.0%	Conforms	HS-GC
pH	4.5~7.0	5.10
Related substance	Spot not bigger than standard solution spot	No spot	TLC
Water Content	≤2%	0.26%	KF
Assay (dried basis)	98.0%--102.0%	99.48%	Potentiometric titration
Assay (dried basis)	98.5%--100%	99.2%	HPLC

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