Sirolimus Rapamycin Powder

Pharmaceutical Grade Pure 99% Sirolimus Rapamycin Powder CAS 53123-88-9

Igama lemveliso:
Sirolimus Rapamycin Powder
Ibakala:
Pharmaceutical grade
Iinkcazelo ngeempawu:
umgubo omhlophe
Ukupakisha:
25kg/igubu
MOQ:
1 kilo
Ugcino:Indawo eyomileyo epholileyo
Beka ubomi kwishelufa:iminyaka eyi-2

QHAGAMSHELANA NGOKU PDF Khuphela

Iinkcukacha

Iithegi

Ingcaciso yeMveliso

Rapamycin is produced by the soil bacterium Streptomyces hygroscopicus. The drug's name comes from Rapa Nui, the indigenous name of Easter Island, where the compound was originally discovered in soil samples in the 1970s.

Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.

Isicelo

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.

Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

Iingenelo

Sinemizi-mveliso emininzi ekumgangatho ophezulu enentsebenziswano enzulu, enokubonelela ngeemveliso ezikumgangatho ophezulu kunye namaxabiso akhuphisanayo. Kwaye sinako ukunika izaphulelo zokuthengwa kwezinto ezininzi.Kwaye siyasebenzisana neenkampani ezininzi zokuthunyelwa kwempahla, zinokuzisa iimveliso ngokukhuselekileyo nangokutyibilikayo ezandleni zakho. Ixesha lokuhambisa limalunga neentsuku ezi-3-20 emva kokuqinisekiswa kwentlawulo.

Inkcazo

ITEM	INGCACISO	RESULT	METHOD
Imbonakalo	White powder, neutral odor, highly hygroscopic	Iyahambelana	Visual
Ukuchongwa	Standard solution and test solution same spot,RF	Iyahambelana	TLC
Specific Optical	-2.4°~ -2.8°	-2.72°
Heavy metals (as PB)	≤10ppm	Iyahambelana	AAS
Sulfate (SO4)	≤0.02%	Iyahambelana	Colorimetry
Chloride (Cl)	≤0.02%	Iyahambelana	Colorimetry
Phosphate Ion (P)	≤5ppm	Iyahambelana	Colorimetry
Residual solvent(ethanol)	≤1.0%	Iyahambelana	HS-GC
pH	4.5~7.0	5.10
Related substance	Spot not bigger than standard solution spot	No spot	TLC
Water Content	≤2%	0.26%	KF
Assay (dried basis)	98.0%--102.0%	99.48%	Potentiometric titration
Assay (dried basis)	98.5%--100%	99.2%	HPLC

Ukuthunyelwa kunye nentlawulo

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