Heparin sodium, an anticoagulant, is a mucopolysaccharide. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. It is secreted by mast cell in the human body and naturally exists in the blood. Heparin sodium has the function of preventing platelet aggregation and destruction, inhibiting the transformation of fibrinogen into fibrin monomers, inhibiting the formation of thromboplastin and antagonizing the formed thromboplastin, preventing the transformation of prothrombin into thrombin, and antagonizing thrombin.
1. Biochemical studies; used for preventing the conversion of prothrombin into thrombin; has blood anti-thrombosis effect.
2. For the delay and prevention of blood clotting.
3.Heparin sodium salt is a mucopolysaccharides biochemical medicine extracted from porcine small intestinal mucosa with strong anticoagulant activity. Mclcan found it from the liver tissue of dog in the study of the clotting mechanism. Brinkous et al proved that heparin having anticoagulant activity. After the first application of heparin as an anticoagulant in clinical filed, it has drawn worldwide attention. With a strong anticoagulant effect, heparin is the primary choice for prevention and treatment of deep vein thrombosis and other thrombotic diseases.
1. The treatment of various diseases concurrent disseminated intravascular coagulation early.
2. Prevention of arterial and venous thrombosis and pulmonary embolism.
3. Treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina
(to alleviate the symptoms, prevention of myocardial infarction), acute myocardial infarction (prevention of
early reinfarction and infarct extension, reduce mortality).
4. The artificial lung, peritoneal dialysis or hemodialysis as anticoagulants.
5. thrombolytic therapy as maintenance therapy.
6. Heparin lithium used for the prevention of blood coagulation and blood bank transfusion of blood and
other body save my save.
ພວກເຮົາມີໂຮງງານທີ່ມີຄຸນນະພາບສູງຫຼາຍທີ່ມີການຮ່ວມມືຢ່າງເລິກເຊິ່ງ, ເຊິ່ງສາມາດໃຫ້ທ່ານຜະລິດຕະພັນທີ່ມີຄຸນນະພາບສູງແລະລາຄາທີ່ແຂ່ງຂັນ. ແລະພວກເຮົາຍັງສາມາດໃຫ້ສ່ວນຫຼຸດສໍາລັບການຊື້ຈໍານວນຫລາຍ.ແລະພວກເຮົາຮ່ວມມືກັບບໍລິສັດຂົນສົ່ງສິນຄ້າມືອາຊີບຈໍານວນຫຼາຍ, ສາມາດຈັດສົ່ງຜະລິດຕະພັນໄດ້ຢ່າງປອດໄພແລະກ້ຽງກັບມືຂອງທ່ານ. ເວລາສົ່ງແມ່ນປະມານ 3-20 ມື້ຫຼັງຈາກຢືນຢັນການຈ່າຍເງິນ.
检验项目 ລາຍການ |
ມາດຕະຖານ |
检验结果 test result |
ຮູບລັກສະນະ |
White or almost white hygroscopic powder |
ປະຕິບັດຕາມ |
Solubility |
Freely soluble in water |
ປະຕິບັດຕາມ |
Identification A |
It delays the clothing of recalcified citrated sheep plasma. |
ປະຕິບັດຕາມ |
Identification B |
1H-NMR |
ປະຕິບັດຕາມ |
Identification C |
In the chromatogram of related substance, the principal peak obtained with test solution is similar in retention time and shape to the principal peak in the chromatogram obtained with reference solution. |
ປະຕິບັດຕາມ |
Identification D |
It complies with the test for sodium |
ປະຕິບັດຕາມ |
Appearance of solution |
A: The solution is clear. |
ປະຕິບັດຕາມ |
B: The solution is not more intensely coloured than reference solution Y5. |
ປະຕິບັດຕາມ |
|
PH |
5.5~8.0 |
7.3 |
Nucleotidic impurities |
Absorbance at 260 nm: ≤0.15 |
0.041 |
Protein |
≤0.5%(Dried substance) |
0.06% |
Related substances |
Dermatan Sulfate+Chondroitin Sulfate: not more than the area of the peak due to dermatan sulfate and chondroitin sulfate in the chromatogram obtained with reference solution (e)(2.0%) |
<0.1% |
Any other impurity: No peaks other than the peak due to dermatan sulfate+chondroitin sulfate are detected |
ລົບ |
|
Nitrogen |
1.5%~2.5%(Dried substance) |
2.10% |
Sodium |
10.5%~13.5%(Dried substance) |
11.90% |
Heavy metals |
≤30ppm |
ປະຕິບັດຕາມ |
Loss on drying |
≤8.0% |
1.00% |
Becterial endotoxins |
<0.01 IU/IU |
ປະຕິບັດຕາມ |
Protency |
|
156 IU/mg |
Potency(dried substance) |
≥150 IU/mg(Dried substance) |
158 IU/mg |
Specific rotation |
≥+50° |
:+55° |
Molecular weight determinations |
Mw: 15,000~ 19,000Da; M24000~≤20%; ~ ≥1.0 |
15100 11% 2.3 |
Residual solvents |
Ethanol≤4500ppm |
1298ppm |
Microbial contamination |
A: TAMC≤10 CFU/g TYMC≤10 CFU/g B: Specified micro organisms Escherichia coli: negative Salmonella: negative Pseudomonas aeruginosa: negative |
<10 CFU/g <10 CFU/g Negative Negative negative |
Detection conclusion |
Comply with the EP & In-house specification. |
Heparin sodium salt, used as an anticoagulant, is a mucopolysaccharide substance, is the sodium salt form of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle, and sheep. It is secreted by mast cells to be naturally presented the blood inside the human bodies. Heparin can prevent platelet aggregation and destruction, inhibit the conversion from fibrinogen to fibrin monomers, inhibit the formation of thromboplastin and fight against the pre-formed thromboplastin, and also prevent the conversion of prothrombin to thrombin and counteract the antithrombin.
Heparin sodium can delay or prevent blood clotting both in vivo and in vitro. Its mechanism of action is extremely complex and has an impact on many aspects of the coagulation process. Its function is:
1,to inhibit the formation and action of coagulation activating enzymes, thereby preventing the transformation of prothrombin into thrombin;
2,At high concentrations, it has the effect of inhibiting thrombin and other coagulation factors, hindering the transformation of fibrinogen into fibrin;
3,It can prevent the aggregation and destruction of platelet chemobooks. In addition, the anticoagulant effect of heparin sodium is still related to the negatively charged sulfate ions in its molecules. Positive charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, thus inhibiting its anticoagulant effect. Due to the activation and release of lipoprotein esterase by heparin in the body, it hydrolyzes the triglycerides and low-density lipoprotein of chyle particles, resulting in a lipid-lowering effect.
1. ເຈົ້າເປັນໂຮງງານຫຼືບໍລິສັດການຄ້າບໍ?
ພວກເຮົາແມ່ນ compnay ອຸດສາຫະກໍາປະສົມປະສານແລະການຄ້າ, ການສະຫນອງການບໍລິການທີ່ຢຸດດຽວ.OEM ສາມາດໄດ້ຮັບການຍອມຮັບ.
2. ເຈົ້າໃຫ້ຕົວຢ່າງບໍ? ມັນບໍ່ເສຍຄ່າຫຼືພິເສດບໍ?
ຕົວຢ່າງຟຣີ.ຄ່າທໍານຽມການຂົນສົ່ງຂອງຕົວຢ່າງຈໍາເປັນຕ້ອງຈ່າຍໂດຍຂ້າງຂອງທ່ານ.
3. ທ່ານມີໃບຢັ້ງຢືນທີ່ກ່ຽວຂ້ອງກັບການຄວບຄຸມຄຸນນະພາບບໍ?
ການຢັ້ງຢືນ ISO 9001: 2008 ເພື່ອຮັບປະກັນຄຸນນະພາບ.
4. ຂ້ອຍຄວນຈັດຫາຫຍັງເພື່ອໃຫ້ໄດ້ໃບສະເໜີລາຄາ?
Pls ແຈ້ງພວກເຮົາກ່ຽວກັບປະເພດຜະລິດຕະພັນທີ່ທ່ານຕ້ອງການ, ຈໍານວນການສັ່ງຊື້, ທີ່ຢູ່ແລະຄວາມຕ້ອງການສະເພາະ.
5. ເຈົ້າມັກວິທີຈ່າຍເງິນແບບໃດ? ປະເພດໃດແດ່ທີ່ຍອມຮັບ?
ເງື່ອນໄຂການຈັດສົ່ງທີ່ຍອມຮັບ: FOB, CFR, CIF, EXW;
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