Heparin sodium, an anticoagulant, is a mucopolysaccharide. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. It is secreted by mast cell in the human body and naturally exists in the blood. Heparin sodium has the function of preventing platelet aggregation and destruction, inhibiting the transformation of fibrinogen into fibrin monomers, inhibiting the formation of thromboplastin and antagonizing the formed thromboplastin, preventing the transformation of prothrombin into thrombin, and antagonizing thrombin.
1. Biochemical studies; used for preventing the conversion of prothrombin into thrombin; has blood anti-thrombosis effect.
2. For the delay and prevention of blood clotting.
3.Heparin sodium salt is a mucopolysaccharides biochemical medicine extracted from porcine small intestinal mucosa with strong anticoagulant activity. Mclcan found it from the liver tissue of dog in the study of the clotting mechanism. Brinkous et al proved that heparin having anticoagulant activity. After the first application of heparin as an anticoagulant in clinical filed, it has drawn worldwide attention. With a strong anticoagulant effect, heparin is the primary choice for prevention and treatment of deep vein thrombosis and other thrombotic diseases.
1. The treatment of various diseases concurrent disseminated intravascular coagulation early.
2. Prevention of arterial and venous thrombosis and pulmonary embolism.
3. Treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina
(to alleviate the symptoms, prevention of myocardial infarction), acute myocardial infarction (prevention of
early reinfarction and infarct extension, reduce mortality).
4. The artificial lung, peritoneal dialysis or hemodialysis as anticoagulants.
5. thrombolytic therapy as maintenance therapy.
6. Heparin lithium used for the prevention of blood coagulation and blood bank transfusion of blood and
other body save my save.
Muna da masana'antu masu inganci da yawa tare da haɗin gwiwa mai zurfi, wanda zai iya ba ku samfuran inganci da farashin gasa. Kuma muna iya ba da rangwamen kuɗi don sayayya mai yawa. Kuma muna ba da haɗin kai tare da ƙwararrun kamfanoni masu jigilar kaya, za su iya isar da samfuran cikin aminci da kwanciyar hankali ga hannunku. Lokacin bayarwa shine kimanin kwanaki 3-20 bayan tabbatar da biyan kuɗi.
检验项目 Abu |
Matsayi |
检验结果 test result |
Bayyanar |
White or almost white hygroscopic powder |
Ya bi |
Solubility |
Freely soluble in water |
Ya bi |
Identification A |
It delays the clothing of recalcified citrated sheep plasma. |
Ya bi |
Identification B |
1H-NMR |
Ya bi |
Identification C |
In the chromatogram of related substance, the principal peak obtained with test solution is similar in retention time and shape to the principal peak in the chromatogram obtained with reference solution. |
Ya bi |
Identification D |
It complies with the test for sodium |
Ya bi |
Appearance of solution |
A: The solution is clear. |
Ya bi |
B: The solution is not more intensely coloured than reference solution Y5. |
Ya bi |
|
PH |
5.5~8.0 |
7.3 |
Nucleotidic impurities |
Absorbance at 260 nm: ≤0.15 |
0.041 |
Protein |
≤0.5%(Dried substance) |
0.06% |
Related substances |
Dermatan Sulfate+Chondroitin Sulfate: not more than the area of the peak due to dermatan sulfate and chondroitin sulfate in the chromatogram obtained with reference solution (e)(2.0%) |
<0.1% |
Any other impurity: No peaks other than the peak due to dermatan sulfate+chondroitin sulfate are detected |
Korau |
|
Nitrogen |
1.5%~2.5%(Dried substance) |
2.10% |
Sodium |
10.5%~13.5%(Dried substance) |
11.90% |
Karfe masu nauyi |
≤30ppm |
Ya bi |
Loss on drying |
≤8.0% |
1.00% |
Becterial endotoxins |
<0.01 IU/IU |
Ya bi |
Protency |
|
156 IU/mg |
Potency(dried substance) |
≥150 IU/mg(Dried substance) |
158 IU/mg |
Specific rotation |
≥+50° |
:+55° |
Molecular weight determinations |
Mw: 15,000~ 19,000Da; M24000~≤20%; ~ ≥1.0 |
15100 11% 2.3 |
Residual solvents |
Ethanol≤4500ppm |
1298ppm |
Microbial contamination |
A: TAMC≤10 CFU/g TYMC≤10 CFU/g B: Specified micro organisms Escherichia coli: negative Salmonella: negative Pseudomonas aeruginosa: negative |
<10 CFU/g <10 CFU/g Negative Negative negative |
Detection conclusion |
Comply with the EP & In-house specification. |
Heparin sodium salt, used as an anticoagulant, is a mucopolysaccharide substance, is the sodium salt form of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle, and sheep. It is secreted by mast cells to be naturally presented the blood inside the human bodies. Heparin can prevent platelet aggregation and destruction, inhibit the conversion from fibrinogen to fibrin monomers, inhibit the formation of thromboplastin and fight against the pre-formed thromboplastin, and also prevent the conversion of prothrombin to thrombin and counteract the antithrombin.
Heparin sodium can delay or prevent blood clotting both in vivo and in vitro. Its mechanism of action is extremely complex and has an impact on many aspects of the coagulation process. Its function is:
1,to inhibit the formation and action of coagulation activating enzymes, thereby preventing the transformation of prothrombin into thrombin;
2,At high concentrations, it has the effect of inhibiting thrombin and other coagulation factors, hindering the transformation of fibrinogen into fibrin;
3,It can prevent the aggregation and destruction of platelet chemobooks. In addition, the anticoagulant effect of heparin sodium is still related to the negatively charged sulfate ions in its molecules. Positive charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, thus inhibiting its anticoagulant effect. Due to the activation and release of lipoprotein esterase by heparin in the body, it hydrolyzes the triglycerides and low-density lipoprotein of chyle particles, resulting in a lipid-lowering effect.
1. Shin ku masana'anta ne ko kamfani na kasuwanci?
Mu kamfani ne mai haɗa masana'antu da kasuwanci, samar da sabis na tsayawa ɗaya. Ana iya karɓar OEM.
2. Kuna samar da samfurori? Yana da kyauta ko kari?
Samfuran kyauta. Ana buƙatar biyan kuɗin jigilar samfurin ta gefen ku.
3. Kuna da wasu takaddun shaida masu alaƙa da kula da inganci?
ISO 9001: 2008 takardar shaida don tabbatar da inganci.
4. Menene zan bayar don samun zance?
Pls sanar da mu nau'in samfurin wanda kuke buƙata, adadin oda, adireshi da takamaiman buƙatu. Za a yi zance don bayanin ku cikin lokaci.
5. Wane irin hanyar biyan kuɗi kuka fi so? Wane irin sharuɗɗan ne ake karɓa?
Sharuɗɗan Isar da Karɓa: FOB, CFR, CIF, EXW;
Kudin Biyan Da Aka Karɓa: USD;
Nau'in Biyan Da Aka Karɓa: T/T, Western Union; Paypal, Tabbacin Kasuwanci.
Harshe Ana Magana: Turanci.
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