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Heparin Sodium

High Purity Supply Heparin Sodium with low price CAS: 9041-08-1

 

  • Име на продукта:

    Heparin Sodium

  • степен:

    Pharmaceutical grade

  • Имоти:

    Бяла пудра

  • Опаковане:

    25kg/bag/drum

  • MOQ:

    1 ton

  • Съхранение:Хладно и сухо място
  • Срок на годност:2 години


Подробности

Тагове

Описание на продукта

 

Heparin sodium, an anticoagulant, is a mucopolysaccharide. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. It is secreted by mast cell in the human body and naturally exists in the blood. Heparin sodium has the function of preventing platelet aggregation and destruction, inhibiting the transformation of fibrinogen into fibrin monomers, inhibiting the formation of thromboplastin and antagonizing the formed thromboplastin, preventing the transformation of prothrombin into thrombin, and antagonizing thrombin.

 

Дисплей на продукта

 

 

Характеристика

 

1. Biochemical studies; used for preventing the conversion of prothrombin into thrombin; has blood anti-thrombosis effect.
2. For the delay and prevention of blood clotting.
3.
Heparin sodium salt is a mucopolysaccharides biochemical medicine extracted from porcine small intestinal mucosa with strong anticoagulant activity. Mclcan found it from the liver tissue of dog in the study of the clotting mechanism. Brinkous et al proved that heparin having anticoagulant activity. After the first application of heparin as an anticoagulant in clinical filed, it has drawn worldwide attention. With a strong anticoagulant effect, heparin is the primary choice for prevention and treatment of deep vein thrombosis and other thrombotic diseases.

 

Приложение

 

1. The treatment of various diseases concurrent disseminated intravascular coagulation early.
2. Prevention of arterial and venous thrombosis and pulmonary embolism.
3. Treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina
(to alleviate the symptoms, prevention of myocardial infarction), acute myocardial infarction (prevention of
early reinfarction and infarct extension, reduce mortality).
4. The artificial lung, peritoneal dialysis or hemodialysis as anticoagulants.
5. thrombolytic therapy as maintenance therapy.
6. Heparin lithium used for the prevention of blood coagulation and blood bank transfusion of blood and
other body save my save.

 

Предимства

 

Имаме много висококачествени фабрики с дълбоко сътрудничество, които могат да ви осигурят висококачествени продукти и конкурентни цени. И ние можем да дадем отстъпки за покупки на едро. И ние си сътрудничим с много професионални спедиторски компании, можем да доставим продукти безопасно и гладко до вашите ръце. Времето за доставка е около 3-20 дни след потвърждение на плащането.

Спецификация

 

检验项目 Вещ

Стандарти

检验结果  test result

Външен вид

White or almost white hygroscopic powder

Съответства

Solubility

Freely soluble in water

Съответства

 

Identification A

It delays the clothing of   recalcified citrated sheep plasma.

 

Съответства

Identification B

1H-NMR

Съответства

 

 

 

 

Identification C

 

In the chromatogram of related substance, the principal peak    obtained with test solution is     similar in retention time and

shape to the principal peak in the chromatogram obtained    with reference solution.

 

 

 

 

Съответства

Identification D

It complies with the test for sodium

Съответства

 

 

Appearance of solution

A: The solution is clear.

Съответства

B: The solution is not more intensely coloured than

reference solution Y5.

 

Съответства

PH

5.5~8.0

7.3

Nucleotidic impurities

Absorbance at 260 nm: ≤0.15

0.041

Protein

≤0.5%(Dried substance)

0.06%

 

 

 

 

 

 

Related substances

 

Dermatan Sulfate+Chondroitin  Sulfate: not more than the area of the peak due to dermatan

sulfate and chondroitin sulfate in the chromatogram obtained

with reference solution (e)(2.0%)

 

 

 

 

<0.1%

Any other impurity:

No peaks other than the peak due to dermatan

sulfate+chondroitin sulfate are detected

 

 

Отрицателна

Nitrogen

1.5%~2.5%(Dried substance)

2.10%

Sodium

10.5%~13.5%(Dried substance)

11.90%

Тежки метали

≤30ppm

Съответства

Loss on drying

≤8.0%

1.00%

Becterial endotoxins

<0.01 IU/IU

Съответства

Protency

 

156 IU/mg

Potency(dried substance)

≥150 IU/mg(Dried substance)

158 IU/mg

Specific rotation

≥+50°

:+55°

 

Molecular weight determinations

Mw: 15,000~ 19,000Da;

M24000~≤20%;              ~

≥1.0

15100

11%

2.3

Residual solvents

Ethanol≤4500ppm

1298ppm

 

 

 

 

 

Microbial contamination

A: TAMC≤10 CFU/g TYMC≤10 CFU/g

B: Specified micro organisms Escherichia coli:

negative

Salmonella:               negative Pseudomonas aeruginosa:

negative

 

 

<10 CFU/g <10 CFU/g

Negative Negative negative

Detection conclusion

Comply with the EP & In-house specification.

 

Познаване на продукта:

 

Heparin sodium salt, used as an anticoagulant, is a mucopolysaccharide substance, is the sodium salt form of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle, and sheep. It is secreted by mast cells to be naturally presented the blood inside the human bodies. Heparin can prevent platelet aggregation and destruction, inhibit the conversion from fibrinogen to fibrin monomers, inhibit the formation of thromboplastin and fight against the pre-formed thromboplastin, and also prevent the conversion of prothrombin to thrombin and counteract the antithrombin.

Heparin sodium can delay or prevent blood clotting both in vivo and in vitro. Its mechanism of action is extremely complex and has an impact on many aspects of the coagulation process. Its function is:

1,to inhibit the formation and action of coagulation activating enzymes, thereby preventing the transformation of prothrombin into thrombin;
2,At high concentrations, it has the effect of inhibiting thrombin and other coagulation factors, hindering the transformation of fibrinogen into fibrin;
3,It can prevent the aggregation and destruction of platelet chemobooks. In addition, the anticoagulant effect of heparin sodium is still related to the negatively charged sulfate ions in its molecules. Positive charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, thus inhibiting its anticoagulant effect. Due to the activation and release of lipoprotein esterase by heparin in the body, it hydrolyzes the triglycerides and low-density lipoprotein of chyle particles, resulting in a lipid-lowering effect.

 

Доставка и плащане

 

 

ЧЗВ

 

1. Вие сте фабрика или търговско дружество?
Ние сме компания, която интегрира индустрията и търговията, предоставяйки обслужване на едно гише. OEM може да бъде прието.

2. Предоставяте ли мостри? Безплатно ли е или допълнително?
Безплатни проби. Таксата за транспорт на пробата трябва да бъде платена от ваша страна.

3. Имате ли сертификати, свързани с контрола на качеството?
Сертифициране по ISO 9001:2008 за гарантиране на качеството.

4. Какво трябва да предоставя, за да получа оферта?
Моля, информирайте ни за вида на продукта, от който се нуждаете, количеството на поръчката, адреса и специфичните изисквания. Офертата ще бъде направена за ваша справка навреме.

5. Какъв метод на плащане предпочитате? Какви условия се приемат?
Приети условия за доставка: FOB, CFR, CIF, EXW;
Приета валута на плащане: USD;
Приет тип плащане: T/T, Western Union; Paypal, търговска гаранция.
Говорим език: Английски.

 

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