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Heparin Sodium

High Purity Supply Heparin Sodium with low price CAS: 9041-08-1

 

  • Dzina la malonda:

    Heparin Sodium

  • Gulu:

    Pharmaceutical grade

  • Katundu:

    ufa woyera

  • Kulongedza:

    25kg/bag/drum

  • MOQ:

    1 ton

  • Posungira:Malo Ozizira Owuma
  • Alumali moyo:zaka 2


Tsatanetsatane

Tags

Mafotokozedwe Akatundu

 

Heparin sodium, an anticoagulant, is a mucopolysaccharide. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. It is secreted by mast cell in the human body and naturally exists in the blood. Heparin sodium has the function of preventing platelet aggregation and destruction, inhibiting the transformation of fibrinogen into fibrin monomers, inhibiting the formation of thromboplastin and antagonizing the formed thromboplastin, preventing the transformation of prothrombin into thrombin, and antagonizing thrombin.

 

Chiwonetsero cha Zamalonda

 

 

Mawonekedwe

 

1. Biochemical studies; used for preventing the conversion of prothrombin into thrombin; has blood anti-thrombosis effect.
2. For the delay and prevention of blood clotting.
3.
Heparin sodium salt is a mucopolysaccharides biochemical medicine extracted from porcine small intestinal mucosa with strong anticoagulant activity. Mclcan found it from the liver tissue of dog in the study of the clotting mechanism. Brinkous et al proved that heparin having anticoagulant activity. After the first application of heparin as an anticoagulant in clinical filed, it has drawn worldwide attention. With a strong anticoagulant effect, heparin is the primary choice for prevention and treatment of deep vein thrombosis and other thrombotic diseases.

 

Kugwiritsa ntchito

 

1. The treatment of various diseases concurrent disseminated intravascular coagulation early.
2. Prevention of arterial and venous thrombosis and pulmonary embolism.
3. Treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina
(to alleviate the symptoms, prevention of myocardial infarction), acute myocardial infarction (prevention of
early reinfarction and infarct extension, reduce mortality).
4. The artificial lung, peritoneal dialysis or hemodialysis as anticoagulants.
5. thrombolytic therapy as maintenance therapy.
6. Heparin lithium used for the prevention of blood coagulation and blood bank transfusion of blood and
other body save my save.

 

Ubwino wake

 

Tili ndi mafakitale apamwamba kwambiri omwe ali ndi mgwirizano wozama, omwe angakupatseni mankhwala apamwamba kwambiri komanso mitengo yampikisano. Ndipo titha kuperekanso kuchotsera pogula zinthu zambiri.Ndipo timagwirizana ndi makampani ambiri otumiza katundu, amatha kubweretsa zinthu mosatekeseka m'manja mwanu. Kutumiza nthawi ndi za 3-20 masiku chitsimikiziro cha malipiro.

Kufotokozera

 

检验项目 Kanthu

Miyezo

检验结果  test result

Maonekedwe

White or almost white hygroscopic powder

Zimagwirizana

Solubility

Freely soluble in water

Zimagwirizana

 

Identification A

It delays the clothing of   recalcified citrated sheep plasma.

 

Zimagwirizana

Identification B

1H-NMR

Zimagwirizana

 

 

 

 

Identification C

 

In the chromatogram of related substance, the principal peak    obtained with test solution is     similar in retention time and

shape to the principal peak in the chromatogram obtained    with reference solution.

 

 

 

 

Zimagwirizana

Identification D

It complies with the test for sodium

Zimagwirizana

 

 

Appearance of solution

A: The solution is clear.

Zimagwirizana

B: The solution is not more intensely coloured than

reference solution Y5.

 

Zimagwirizana

PH

5.5~8.0

7.3

Nucleotidic impurities

Absorbance at 260 nm: ≤0.15

0.041

Protein

≤0.5%(Dried substance)

0.06%

 

 

 

 

 

 

Related substances

 

Dermatan Sulfate+Chondroitin  Sulfate: not more than the area of the peak due to dermatan

sulfate and chondroitin sulfate in the chromatogram obtained

with reference solution (e)(2.0%)

 

 

 

 

<0.1%

Any other impurity:

No peaks other than the peak due to dermatan

sulfate+chondroitin sulfate are detected

 

 

Zoipa

Nitrogen

1.5%~2.5%(Dried substance)

2.10%

Sodium

10.5%~13.5%(Dried substance)

11.90%

Zitsulo zolemera

≤30ppm

Zimagwirizana

Loss on drying

≤8.0%

1.00%

Becterial endotoxins

<0.01 IU/IU

Zimagwirizana

Protency

 

156 IU/mg

Potency(dried substance)

≥150 IU/mg(Dried substance)

158 IU/mg

Specific rotation

≥+50°

:+55°

 

Molecular weight determinations

Mw: 15,000~ 19,000Da;

M24000~≤20%;              ~

≥1.0

15100

11%

2.3

Residual solvents

Ethanol≤4500ppm

1298ppm

 

 

 

 

 

Microbial contamination

A: TAMC≤10 CFU/g TYMC≤10 CFU/g

B: Specified micro organisms Escherichia coli:

negative

Salmonella:               negative Pseudomonas aeruginosa:

negative

 

 

<10 CFU/g <10 CFU/g

Negative Negative negative

Detection conclusion

Comply with the EP & In-house specification.

 

Kudziwa kwazinthu:

 

Heparin sodium salt, used as an anticoagulant, is a mucopolysaccharide substance, is the sodium salt form of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle, and sheep. It is secreted by mast cells to be naturally presented the blood inside the human bodies. Heparin can prevent platelet aggregation and destruction, inhibit the conversion from fibrinogen to fibrin monomers, inhibit the formation of thromboplastin and fight against the pre-formed thromboplastin, and also prevent the conversion of prothrombin to thrombin and counteract the antithrombin.

Heparin sodium can delay or prevent blood clotting both in vivo and in vitro. Its mechanism of action is extremely complex and has an impact on many aspects of the coagulation process. Its function is:

1,to inhibit the formation and action of coagulation activating enzymes, thereby preventing the transformation of prothrombin into thrombin;
2,At high concentrations, it has the effect of inhibiting thrombin and other coagulation factors, hindering the transformation of fibrinogen into fibrin;
3,It can prevent the aggregation and destruction of platelet chemobooks. In addition, the anticoagulant effect of heparin sodium is still related to the negatively charged sulfate ions in its molecules. Positive charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, thus inhibiting its anticoagulant effect. Due to the activation and release of lipoprotein esterase by heparin in the body, it hydrolyzes the triglycerides and low-density lipoprotein of chyle particles, resulting in a lipid-lowering effect.

 

Kutumiza ndi kulipira

 

 

FAQ

 

1. Kodi ndinu fakitale kapena kampani yamalonda?
Ndife compnay kuphatikiza makampani ndi malonda, kupereka amodzi-stop service.OEM akhoza kulandiridwa.

2. Kodi mumapereka zitsanzo? Ndi zaulere kapena zowonjezera?
Zitsanzo zaulere. Ndalama zonyamula katundu zachitsanzo ziyenera kulipidwa ndi mbali yanu.

3. Kodi muli ndi ziphaso zilizonse zokhudzana ndi kuwongolera bwino?
ISO 9001:2008 certification kuti mutsimikizire mtundu.

4. Kodi ndiyenera kupereka chiyani kuti ndilandireko mawu?
Pls amatiuza za mtundu wazinthu zomwe mukufuna, kuchuluka kwa madongosolo, ma adilesi ndi zofunikira zenizeni.

5. Mumakonda njira yolipira yanji? Ndi mawu otani omwe amavomerezedwa?
Malamulo Ovomerezeka Ovomerezeka: FOB,CFR,CIF,EXW;
Ndalama Zolipira Zovomerezeka: USD;
Mtundu wa Malipiro Ovomerezeka: T/T,Western Union; Paypal, Trade Assurance.
Chiyankhulo Cholankhulidwa:Chingerezi.

 

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