Nicorandil

High Purity 99% Assay Nicorandil Pharmaceuticals Powder with CAS 65141-46-0

Izina RY'IGICURUZWA:
Nicorandil
Icyiciro:
Pharmaceutical Grade
Ibyiza:
ifu yera
Gupakira:
25kg / ingoma
MOQ:
1 ton
Ububiko:Ahantu humye
Ubuzima bwa Shelf:Imyaka 2

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Ibisobanuro

Etiquetas

Ibisobanuro ku bicuruzwa

Nicorandil is N-(2-hydroxyethyl)-nicotinamide nitrate (ester). It is a white crystalline powder or white needles with a faint, characteristic odour. It is freely soluble in methan ol, ethanol, aceto ne or glacial acetic acid, slightly soluble in chloro form or water, almost insoluble in ether or benzene. Melting point 88.5-93.5 ºC. Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously.Nicorandil is a nitric oxid e donor and ATP-sensitive potassium channel opener. A study showed that Nicorandil is able to protect against stress-induced cell death in dystrophin-deficient cardiomyocytes and also preserve cardiac function in the mdx mouse heart subjected to ischemia and reperfusion injury.

Ibyiza

Dufite inganda nyinshi zo mu rwego rwo hejuru hamwe nubufatanye bwimbitse, zishobora kuguha ibicuruzwa byiza kandi nibiciro byapiganwa. Turashobora kandi gutanga kugabanyirizwa kugura byinshi.Kandi turafatanya namasosiyete menshi yohereza ibicuruzwa byumwuga, birashobora gutanga ibicuruzwa neza kandi neza mumaboko yawe. Igihe cyo gutanga ni iminsi 3-20 nyuma yo kwemeza ko wishyuye.

Ibisobanuro

Items	Bisanzwe	Ibisubizo
APPEARANCE	Off white to white powder	Ifu yera
IDENTIFICATION	A: IR B: Retention time	Bikubiyemo Bikubiyemo
WATER	≤0.5%	0.06%
HEAVY METALS	≤0.002%	Bikubiyemo
ISOMERS	SFBD1≤0.15%	Undetected
	SFBD2≤0.15%	Undetected
	SFBE≤0.15%	Undetected
RELATED SUBSTANCES	SFBA-1≤0.15%	0.04%
	SFBMA≤0.15%	Undetected
	CHLORO-SFB≤0.15%	0.05%
	DiSFBMA-SFB≤0.15%	0.02%
	Methyl-SFB≤0.15%	Undetected
	Pentafluoro-phenol≤0.15%	Undetected
	Amino-SFB≤0.15%	Undetected
	Any unknown impurity≤0.1%	0.04%
	Total impurity≤1.0%	0.21%
RESIDUE SOLBENTS	Methanol≤3000ppm	Undetected
	Isopropyl alcohol≤5000ppm	19ppm
	Dichloromethane≤600ppm	Undetected
	Tetrahydrofuran≤720ppm	Undetected
	Acetic acid≤5000ppm	Undetected
	Toluene≤890ppm	Undetected
	Chlorobenzene≤360ppm	Undetected
	Methyl tert-butyl ether≤5000ppm	103ppm
ASSAY	≥99.0%	99.8%
RESULT: It complies to prescribed enterprise standard

Ubumenyi bwibicuruzwa ：

Nicorandil is used for the prevention and treatment of chronic stable angina. It is usually used when angina becomes difficult to control by other drugs and is given as an additional treatment.

Kohereza no kwishyura

Ibibazo

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