Nicorandil is N-(2-hydroxyethyl)-nicotinamide nitrate (ester). It is a white crystalline powder or white needles with a faint, characteristic odour. It is freely soluble in methan ol, ethanol, aceto ne or glacial acetic acid, slightly soluble in chloro form or water, almost insoluble in ether or benzene. Melting point 88.5-93.5 ºC. Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously.Nicorandil is a nitric oxid e donor and ATP-sensitive potassium channel opener. A study showed that Nicorandil is able to protect against stress-induced cell death in dystrophin-deficient cardiomyocytes and also preserve cardiac function in the mdx mouse heart subjected to ischemia and reperfusion injury.
Mae gennym lawer o ffatrïoedd o ansawdd uchel gyda chydweithrediad dwfn, a all ddarparu cynhyrchion o ansawdd uchel a phrisiau cystadleuol i chi. A gallwn hefyd roi gostyngiadau ar gyfer swmp-brynu. Mae amser dosbarthu tua 3-20 diwrnod ar ôl cadarnhad taliad.
Items | Safonol | Canlyniadau |
APPEARANCE | Off white to white powder | Powdr gwyn |
IDENTIFICATION | A: IR B: Retention time |
Yn cydymffurfio Yn cydymffurfio |
WATER | ≤0.5% | 0.06% |
HEAVY METALS | ≤0.002% | Yn cydymffurfio |
ISOMERS | SFBD1≤0.15% | Undetected |
SFBD2≤0.15% | Undetected | |
SFBE≤0.15% | Undetected | |
RELATED SUBSTANCES | SFBA-1≤0.15% | 0.04% |
SFBMA≤0.15% | Undetected | |
CHLORO-SFB≤0.15% | 0.05% | |
DiSFBMA-SFB≤0.15% | 0.02% | |
Methyl-SFB≤0.15% | Undetected | |
Pentafluoro-phenol≤0.15% | Undetected | |
Amino-SFB≤0.15% | Undetected | |
Any unknown impurity≤0.1% | 0.04% | |
Total impurity≤1.0% | 0.21% | |
RESIDUE SOLBENTS | Methanol≤3000ppm | Undetected |
Isopropyl alcohol≤5000ppm | 19ppm | |
Dichloromethane≤600ppm | Undetected | |
Tetrahydrofuran≤720ppm | Undetected | |
Acetic acid≤5000ppm | Undetected | |
Toluene≤890ppm | Undetected | |
Chlorobenzene≤360ppm | Undetected | |
Methyl tert-butyl ether≤5000ppm | 103ppm | |
ASSAY | ≥99.0% | 99.8% |
RESULT: It complies to prescribed enterprise standard |
Nicorandil is N-(2-hydroxyethyl)-nicotinamide nitrate (ester). It is a white crystalline powder or white needles with a faint, characteristic odour. It is freely soluble in methan ol, ethanol, aceto ne or glacial acetic acid, slightly soluble in chloro form or water, almost insoluble in ether or benzene. Melting point 88.5-93.5 ºC. Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously.
Nicorandil is used for the prevention and treatment of chronic stable angina. It is usually used when angina becomes difficult to control by other drugs and is given as an additional treatment.
1. Ydych chi'n ffatri neu'n gwmni masnachu?
Rydym yn gwmni sy'n integreiddio diwydiant a masnach, yn darparu gwasanaeth un-stop. Gellid derbyn OEM.
2. A ydych chi'n darparu samplau? A yw'n rhad ac am ddim neu'n ychwanegol?
Samplau am ddim. Mae angen talu ffi cludo nwyddau'r sampl gan eich ochr chi.
3. A oes gennych unrhyw dystysgrifau sy'n ymwneud â rheoli ansawdd?
Ardystiad ISO 9001: 2008 i sicrhau ansawdd.
4. Beth ddylwn i ei ddarparu i gael dyfynbris?
Mae Pls yn rhoi gwybod i ni am y math o gynnyrch sydd ei angen arnoch, archebwch faint, cyfeiriad a gofynion penodol. Bydd y dyfynbris yn cael ei wneud ar gyfer eich cyfeirnod mewn pryd.
5. Pa fath o ddull talu sydd orau gennych chi? Pa fath o delerau sy'n cael eu derbyn?
Telerau Cyflwyno a Dderbynnir: FOB, CFR, CIF, EXW;
Arian Talu a Dderbynnir: USD;
Math o Daliad a Dderbynnir: T / T, Western Union; Paypal, Sicrwydd Masnach.
Iaith a siaredir: Saesneg.
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