Nicorandil is N-(2-hydroxyethyl)-nicotinamide nitrate (ester). It is a white crystalline powder or white needles with a faint, characteristic odour. It is freely soluble in methan ol, ethanol, aceto ne or glacial acetic acid, slightly soluble in chloro form or water, almost insoluble in ether or benzene. Melting point 88.5-93.5 ºC. Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously.Nicorandil is a nitric oxid e donor and ATP-sensitive potassium channel opener. A study showed that Nicorandil is able to protect against stress-induced cell death in dystrophin-deficient cardiomyocytes and also preserve cardiac function in the mdx mouse heart subjected to ischemia and reperfusion injury.
Tili ndi mafakitale apamwamba kwambiri omwe ali ndi mgwirizano wozama, omwe angakupatseni mankhwala apamwamba kwambiri komanso mitengo yampikisano. Ndipo titha kuperekanso kuchotsera pogula zinthu zambiri.Ndipo timagwirizana ndi makampani ambiri otumiza katundu, amatha kubweretsa zinthu mosatekeseka m'manja mwanu. Kutumiza nthawi ndi za 3-20 masiku chitsimikiziro cha malipiro.
Items | Standard | Zotsatira |
APPEARANCE | Off white to white powder | White ufa |
IDENTIFICATION | A: IR B: Retention time |
Zimagwirizana Zimagwirizana |
WATER | ≤0.5% | 0.06% |
HEAVY METALS | ≤0.002% | Zimagwirizana |
ISOMERS | SFBD1≤0.15% | Undetected |
SFBD2≤0.15% | Undetected | |
SFBE≤0.15% | Undetected | |
RELATED SUBSTANCES | SFBA-1≤0.15% | 0.04% |
SFBMA≤0.15% | Undetected | |
CHLORO-SFB≤0.15% | 0.05% | |
DiSFBMA-SFB≤0.15% | 0.02% | |
Methyl-SFB≤0.15% | Undetected | |
Pentafluoro-phenol≤0.15% | Undetected | |
Amino-SFB≤0.15% | Undetected | |
Any unknown impurity≤0.1% | 0.04% | |
Total impurity≤1.0% | 0.21% | |
RESIDUE SOLBENTS | Methanol≤3000ppm | Undetected |
Isopropyl alcohol≤5000ppm | 19ppm | |
Dichloromethane≤600ppm | Undetected | |
Tetrahydrofuran≤720ppm | Undetected | |
Acetic acid≤5000ppm | Undetected | |
Toluene≤890ppm | Undetected | |
Chlorobenzene≤360ppm | Undetected | |
Methyl tert-butyl ether≤5000ppm | 103ppm | |
ASSAY | ≥99.0% | 99.8% |
RESULT: It complies to prescribed enterprise standard |
Nicorandil is N-(2-hydroxyethyl)-nicotinamide nitrate (ester). It is a white crystalline powder or white needles with a faint, characteristic odour. It is freely soluble in methan ol, ethanol, aceto ne or glacial acetic acid, slightly soluble in chloro form or water, almost insoluble in ether or benzene. Melting point 88.5-93.5 ºC. Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously.
Nicorandil is used for the prevention and treatment of chronic stable angina. It is usually used when angina becomes difficult to control by other drugs and is given as an additional treatment.
1. Kodi ndinu fakitale kapena kampani yamalonda?
Ndife compnay kuphatikiza makampani ndi malonda, kupereka amodzi-stop service.OEM akhoza kulandiridwa.
2. Kodi mumapereka zitsanzo? Ndi zaulere kapena zowonjezera?
Zitsanzo zaulere. Ndalama zonyamula katundu zachitsanzo ziyenera kulipidwa ndi mbali yanu.
3. Kodi muli ndi ziphaso zilizonse zokhudzana ndi kuwongolera bwino?
ISO 9001:2008 certification kuti mutsimikizire mtundu.
4. Kodi ndiyenera kupereka chiyani kuti ndilandireko mawu?
Pls amatiuza za mtundu wazinthu zomwe mukufuna, kuchuluka kwa madongosolo, ma adilesi ndi zofunikira zenizeni.
5. Mumakonda njira yolipira yanji? Ndi mawu otani omwe amavomerezedwa?
Malamulo Ovomerezeka Ovomerezeka: FOB,CFR,CIF,EXW;
Ndalama Zolipira Zovomerezeka: USD;
Mtundu wa Malipiro Ovomerezeka: T/T,Western Union; Paypal, Trade Assurance.
Chiyankhulo Cholankhulidwa:Chingerezi.
Magulu azinthu