GS-441524 CAS 1191237-69-0

remdesivir (GS-5734) is a novel nucleoside analogues antiviral developed by GileadScience Company (GileadScience), an RNA-dependent RNA polymeric Chemicalbook enzyme (RdRp) inhibitor. It can play an antiviral role by inhibiting the synthesis of viral nucleic acid. Redesivir is not currently on the market in the world, phase I and Phase II clinical trials for the indication of anti-Ebola virus (filovirus), phase III trials have not yet started.

GS-441524 is a small molecule, riboside triphosphate competitive inhibitor, that has demonstrated strong antiviral activity against many RNA viruses. It can inhibit the replication of several different types of RNA viruses, such as zoonotic severe acute respiratory syndrome (SARS) coronavirus, Middle East Respiratory syndrome virus, Ebola virus, Lassa fever virus, Junin virus, and respiratory syncytial virus, while having low cytotoxicity in a wide range of cell lines.

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