Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam showed cytotoxic activity against cancer cell lines. Demoxepam has anticonvulsant and antianxiety effects.
Chemical property
White crystal (dichloromethane/hexane). Melting point 239-241℃.
5-chloro-3-phenylbenzoisoxazole was synthesized by cyclic synthesis of p-nitrochlorobenzene and benzyl nitrile in ethanol with the participation of sodium hydroxide, then 2-amino-5-chlorobenzophenone was obtained by reduction and ring-opening with iron powder and hydrochloric acid, and then 2-amino-5-chlorobenzophenone oxime was obtained by hydroxylamine hydrochloride. The latter was combined with chloroacetyl chloride to obtain 6-chloro-2-chloromethyl-4-phenylquinazolin-3-oxide, which was then expanded under the action of sodium hydroxide to obtain the product.
1. Intermediates of Anning and Suning (norazepam).
2. It has anti-convulsive and anti-anxiety effects.
Sinezimboni eziningi zekhwalithi ephezulu ngokubambisana okujulile, ezingakunikeza ngemikhiqizo yekhwalithi ephezulu namanani ancintisanayo. Futhi singanikeza izaphulelo zokuthenga ngobuningi.Futhi sibambisana nezinkampani eziningi ezichwepheshile zokudlulisa impahla, zingaletha imikhiqizo ngokuphepha nangokushelela ezandleni zakho. Isikhathi sokulethwa cishe yizinsuku ezi-3-20 ngemuva kokuqinisekiswa kwenkokhelo.
Product Name: | Demoxepam |
Synonyms: | Chlordiazepoxide lactam;NSC-46007;NSC-46077;1,3-Dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide;Ro 5-2092;Ro 5-2092 lactam;ro5-2092;ro5-2092lactam |
CAS: | 963-39-3 |
MF: | C15H11ClN2O2 |
MW: | 286.71 |
EINECS: | 213-515-2 |
Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
Mol File: | 963-39-3.mol |
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Demoxepam Chemical Properties |
Iphoyinti lokuncibilika | 235-236 °C (decomp) |
ukuminyana | 1.40±0.1 g/cm3(Predicted) |
Fp | 2℃ |
izinga lokushisa lokugcina. | -20°C |
ukuncibilika | Chloroform (Slightly), Methanol (Slightly) |
ifomu | Solid |
pka | pKa 4.5 (Uncertain) |
umbala | White to Pale Yellow |
NIST Chemistry Reference | Demoxepam(963-39-3) |
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