Isotretinoic Acid

lsoretinoic acid belongs to the first generation of vitamin A acids. It is a stereoisomer of all trans vitamin A acid. Oral administration has an anti oil effect and has a special effect on severe acne. It has a strong and rapid function of inhibiting the proliferation and differentiation process of skin gland cells. Clinically used for severe acne, cystic acne, and aggregated acne that are ineffective in the treatment of other drugs.Isoretinoic acid is a type of retinol derivative used in acne treatment products, with improved bioavailability and percutaneous absorption. The appearance is yellow orange crystalline powder. Currently, research is being conducted on the combination of photoaging skin treatment.

1. It can reduce sebaceous gland and inhibit the activity of sebaceous gland, reducing the effect of secretion of the sebaceous glands, thus inhibiting the growth of Propionibacterium which relies on lipid environment.

2. It has an anti-keratosis effect, can inhibit the excess proliferation of epidermal and promote its differentiation. It also reduces the keratosis of hair follicles and the catheter of sebaceous glands.

3. It can also affect the function of lymphocytes and monocytes, and inhibit the chemotaxis of neutrophil, and thus having anti-inflammatory activity.

4. It can exert its therapeutic effect by selectively binding Vitamin A acid nuclear receptors. It can inhibit the proliferation of acne rod bacilli. Moreover it has effects of immunity stimulation at low doses, but has immunity suppression effect at high doses.

5. It can inhibit the biogenesis of collagenase and gelatinase in the skin, and can also inhibit the activity of ornithine decarboxylase. Owing to the major role of ornithine decarboxylase in inducing skin mutations, so Isoretinoic can also suppress tumorigenesis.

6. When subjects to topical administration, it has a similar mechanism of action as vitamin A acid which induces the proliferation of epidermal cell, promotes the differentiation of epidermal cell granular layer into the stratum corneum. It can also regulate the horny plug occurring during some abnormal cornification processes of Hair follicle sebaceous epithelium, and thus playing a therapeutic role.

Mayroon kaming maraming mga pabrika na may mataas na kalidad na may malalim na pakikipagtulungan, na maaaring magbigay sa iyo ng mga de-kalidad na produkto at mapagkumpitensyang presyo. At makakapagbigay din kami ng mga diskwento para sa maramihang pagbili. At nakikipagtulungan kami sa maraming propesyonal na kumpanyang nagpapasa ng kargamento, maaaring makapaghatid ng mga produkto nang ligtas at maayos sa iyong mga kamay. Ang oras ng paghahatid ay humigit-kumulang 3-20 araw pagkatapos ng kumpirmasyon ng pagbabayad.

1. Ikaw ba ay isang pabrika o isang kumpanya ng kalakalan?
Kami ay isang compnay na nagsasama ng industriya at kalakalan, na nagbibigay ng one-stop na serbisyo. Maaaring tanggapin ang OEM.

2. Nagbibigay ka ba ng mga sample? Libre ba ito o dagdag?
Libreng sample. Ang bayad sa kargamento ng sample ay kailangang bayaran sa tabi mo.

3. Mayroon ka bang anumang mga sertipiko na may kaugnayan sa kontrol sa kalidad?
ISO 9001:2008 certification para matiyak ang kalidad.

4. Ano ang dapat kong ibigay para makakuha ng quotation?
Pls ipaalam sa amin ang uri ng produkto na kailangan mo, dami ng order, address at mga partikular na kinakailangan. Ang quotation ay gagawin para sa iyong sanggunian sa oras.

5. Anong uri ng paraan ng pagbabayad ang gusto mo? Anong uri ng mga tuntunin ang tinatanggap?
Tinanggap na Mga Tuntunin sa Paghahatid: FOB,CFR,CIF,EXW;
Accepted Payment Currency:USD;EUR
Tinanggap na Uri ng Pagbabayad: T/T,Western Union; Paypal, Trade Assurance.
Wikang Sinasalita:Ingles.