Isotretinoic Acid

lsoretinoic acid belongs to the first generation of vitamin A acids. It is a stereoisomer of all trans vitamin A acid. Oral administration has an anti oil effect and has a special effect on severe acne. It has a strong and rapid function of inhibiting the proliferation and differentiation process of skin gland cells. Clinically used for severe acne, cystic acne, and aggregated acne that are ineffective in the treatment of other drugs.Isoretinoic acid is a type of retinol derivative used in acne treatment products, with improved bioavailability and percutaneous absorption. The appearance is yellow orange crystalline powder. Currently, research is being conducted on the combination of photoaging skin treatment.

1. It can reduce sebaceous gland and inhibit the activity of sebaceous gland, reducing the effect of secretion of the sebaceous glands, thus inhibiting the growth of Propionibacterium which relies on lipid environment.

2. It has an anti-keratosis effect, can inhibit the excess proliferation of epidermal and promote its differentiation. It also reduces the keratosis of hair follicles and the catheter of sebaceous glands.

3. It can also affect the function of lymphocytes and monocytes, and inhibit the chemotaxis of neutrophil, and thus having anti-inflammatory activity.

4. It can exert its therapeutic effect by selectively binding Vitamin A acid nuclear receptors. It can inhibit the proliferation of acne rod bacilli. Moreover it has effects of immunity stimulation at low doses, but has immunity suppression effect at high doses.

5. It can inhibit the biogenesis of collagenase and gelatinase in the skin, and can also inhibit the activity of ornithine decarboxylase. Owing to the major role of ornithine decarboxylase in inducing skin mutations, so Isoretinoic can also suppress tumorigenesis.

6. When subjects to topical administration, it has a similar mechanism of action as vitamin A acid which induces the proliferation of epidermal cell, promotes the differentiation of epidermal cell granular layer into the stratum corneum. It can also regulate the horny plug occurring during some abnormal cornification processes of Hair follicle sebaceous epithelium, and thus playing a therapeutic role.

当社は、緊密な協力関係にある多くの高品質の工場を有しており、高品質の製品と競争力のある価格を提供できます。また、大量購入には割引も提供できます。また、当社は多くの専門の貨物運送会社と協力し、製品を安全かつスムーズにお客様の手元に届けることができます。納期は、支払い確認後約3〜20日です。

1. 貴社は工場ですか、それとも貿易会社ですか?
当社は産業と貿易を統合し、ワンストップサービスを提供する会社です。OEMも受け付けております。

2. サンプルは提供されますか? 無料ですか、それとも追加料金がかかりますか?
サンプルは無料です。サンプルの送料はお客様負担となります。

3. 品質管理に関する証明書はありますか?
品質を保証する ISO 9001:2008 認証。

4. 見積もりを取得するには、何を提供すればよいですか?
必要な製品タイプ、注文数量、住所、具体的な要件をお知らせください。参考用に見積書をすぐに作成いたします。

5. どのような支払い方法をご希望ですか? どのような条件が受け入れられますか?
受け入れられる配送条件: FOB、CFR、CIF、EXW。
Accepted Payment Currency:USD;EUR
受け入れられる支払いタイプ: T/T、Western Union、Paypal、Trade Assurance。
使用言語：英語。