methyl ibogamine-18-carboxylate CAS 467-77-6

methyl ibogamine-18-carboxylate CAS 467-77-6, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1]. Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC50 values >40 μM. It agaisnt wnt-dependent cells with IC50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively[1].Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged[1].In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC30 value for each receptor subtype. 

Ibogamine-18-carboxylic Acid Methyl Ester (CAS# 467-77-6) is a useful research chemical compound. It is used in the biosynthesis of anti-addiction agent from iboga plant.

Re na le lifeme tse ngata tsa boleng bo holimo tse nang le tšebelisano e tebileng, tse ka u fang lihlahisoa tsa boleng bo holimo le litheko tsa tlholisano. Hape re ka fana ka litheolelo bakeng sa ho reka ka bongata.'Me re sebelisana le lik'hamphani tse ngata tsa litsebi tse tsamaisang thepa, li ka isa lihlahisoa ka mokhoa o sireletsehileng le ka thelelo matsohong a hau. Nako ea ho fana e ka ba matsatsi a 3-20 ka mor'a hore ho netefatsoe tefo.

Product Name:	methyl ibogamine-18-carboxylate
Synonyms:	methyl ibogamine-18-carboxylate;coronardine;(-)-Ibogamine-18-carboxylic acid methyl ester;Ibogamine-18-carboxylic acid methyl ester;Coronaridin;NSC 127490;methyl ibogamine
CAS:	467-77-6
MF:	C21H26N2O2
MW:	338.448
EINECS:	207-398-7
Product Categories:
Mol File:	467-77-6.mol

1. Na u feme kapa k'hamphani ea khoebo?
Re komnay e kopanyang indasteri le khoebo, ho fana ka ts'ebeletso e le 'ngoe.OEM e ka amoheloa.

2. O fana ka mehlala? Na ke mahala kapa ho feta?
Mehlala ea mahala. Tefiso ea thepa ea sampole e hloka ho lefuoa ka lehlakore la hau.

3. O na le litifikeiti tse amanang le taolo ea boleng?
Setifikeiti sa ISO 9001:2008 ho netefatsa boleng.

4. Ke fane ka eng ho fumana khotheishene?
Pls re tsebise ka mofuta oa sehlahisoa seo u se hlokang, bongata ba odara, aterese le litlhoko tse ikhethileng. Khotheishene e tla etsoa bakeng sa referense ea hau ka nako.

5. U khetha mofuta ofe oa mokhoa oa ho lefa? Ke mantsoe a mofuta ofe a amoheloang?
Melao e Amoheletsoeng ea Thomello: FOB,CFR,CIF,EXW;
Accepted Payment Currency:USD;EUR
Mofuta oa Tefo o Amoheletsoeng: T/T, Western Union; Paypal, Tiisetso ea Khoebo.
Puo e Builoeng: Senyesemane.