methyl ibogamine-18-carboxylate CAS 467-77-6

methyl ibogamine-18-carboxylate CAS 467-77-6, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1]. Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC50 values >40 μM. It agaisnt wnt-dependent cells with IC50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively[1].Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged[1].In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC30 value for each receptor subtype. 

Ibogamine-18-carboxylic Acid Methyl Ester (CAS# 467-77-6) is a useful research chemical compound. It is used in the biosynthesis of anti-addiction agent from iboga plant.

Loaʻa iā mākou nā hale hana kiʻekiʻe me ka pilina hohonu, hiki iā ia ke hāʻawi iā ʻoe i nā huahana kiʻekiʻe a me nā kumukūʻai hoʻokūkū. A hiki iā mākou ke hāʻawi i nā uku no nā kūʻai nui. A ke hui pū nei mākou me nā ʻoihana lawe ukana ʻoihana he nui, hiki ke hāʻawi i nā huahana me ka palekana a me ka maʻalahi i kou mau lima. ʻO ka manawa hoʻouna ma kahi o 3-20 mau lā ma hope o ka hōʻoia ʻana o ka uku.

Product Name:	methyl ibogamine-18-carboxylate
Synonyms:	methyl ibogamine-18-carboxylate;coronardine;(-)-Ibogamine-18-carboxylic acid methyl ester;Ibogamine-18-carboxylic acid methyl ester;Coronaridin;NSC 127490;methyl ibogamine
CAS:	467-77-6
MF:	C21H26N2O2
MW:	338.448
EINECS:	207-398-7
Product Categories:
Mol File:	467-77-6.mol

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