methyl ibogamine-18-carboxylate CAS 467-77-6

methyl ibogamine-18-carboxylate CAS 467-77-6, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1]. Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC50 values >40 μM. It agaisnt wnt-dependent cells with IC50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively[1].Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged[1].In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC30 value for each receptor subtype. 

Ibogamine-18-carboxylic Acid Methyl Ester (CAS# 467-77-6) is a useful research chemical compound. It is used in the biosynthesis of anti-addiction agent from iboga plant.

Dufite inganda nyinshi zo mu rwego rwo hejuru hamwe nubufatanye bwimbitse, zishobora kuguha ibicuruzwa byiza kandi nibiciro byapiganwa. Turashobora kandi gutanga kugabanyirizwa kugura byinshi.Kandi turafatanya namasosiyete menshi yohereza ibicuruzwa byumwuga, birashobora gutanga ibicuruzwa neza kandi neza mumaboko yawe. Igihe cyo gutanga ni iminsi 3-20 nyuma yo kwemeza ko wishyuye.

Product Name:	methyl ibogamine-18-carboxylate
Synonyms:	methyl ibogamine-18-carboxylate;coronardine;(-)-Ibogamine-18-carboxylic acid methyl ester;Ibogamine-18-carboxylic acid methyl ester;Coronaridin;NSC 127490;methyl ibogamine
URUBANZA:	467-77-6
MF:	C21H26N2O2
MW:	338.448
EINECS:	207-398-7
Product Categories:
Mol File:	467-77-6.mol

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