Sodium 2, 3-dimercaptopropanesulfonate monohydrate is a white crystalline powder soluble in water and alcohol. It has a strong foul odor and pungent odor. It can form coordination compounds containing sulfur divalent.
Intermediate for sodium dimecaptosuccinate(DMS), an antidote for heavy metal.Sodium 2,3-dimercaptopropanesulfonate monohydrate has been used in a study to assess its use as an antidote.
It is a broad-spectrum antidote of heavy metals, and is also used in the therapy of hepatolenticular degeneration, HLD (also known as Wilson's disease). Its effect on hydrargyrism is better than that of dimercaptopropanol, but it has lower toxicity. It is used as antidote of toxicosis from mercury, arsenic, chromium, bismuth, copper, antimony, etc. It is also effective on hepatolenticular degeneration, HLD (Wilson's disease) with long-term use.
Anyị nwere ọtụtụ ụlọ ọrụ dị elu nke nwere nkwado miri emi, nke nwere ike inye gị ngwaahịa dị elu na ọnụ ahịa asọmpi. Anyị nwekwara ike inye ego maka nnukwu ịzụrụ ihe. Anyị na-akwado ọtụtụ ụlọ ọrụ na-ebuga ibu ndị ọkachamara, nwere ike ịnapụta ngwaahịa n'enweghị nsogbu na aka gị. Oge nnyefe bụ ihe dịka ụbọchị 3-20 mgbe nkwenye nke ịkwụ ụgwọ gasịrị.
Tests | Nkọwapụta | Nsonaazụ | |
Ọdịdị | White powder or white-crystalline powder | white-crystalline powder | |
njirimara | Positive NMR | complies | |
Solubility | Freely soluble in water,almost non-soluble in 95% of Ethanol,aether or chloroform. | complies | |
Solution Colority | Solution of 0.7g of substance in 10ml of water has to be colorless | complies | |
Clarity of color | <1# (Reference CP2010) | complies | |
PH | 3.5-5.0 (Reference CP2010) | 4 | |
Heavy metals | ≤10 ppm (Reference CP2010) | complies | |
Residual Solvent | Ethanol:Not More Than 0.5% | N.D | |
Acetic Acid:Not More Than 0.5% | N.D | ||
Substance Related | ≤5% | 1.20% | |
Count of bacteria | Bacillus < 1000 Entries/ 1g | complies | |
Mildew < 100 Entries/ 1g | complies | ||
Microzyme < 100 Entries/ 1g | complies | ||
Loss on drying | ≤ 0.5%(Reference CP2010) | 0.30% | |
Iron | < 50ppm(Reference CP2010) | Na-akwado | |
Assay(Titration) | NLT98% | 99.20% | |
Conclusion:. | Comply with the in-house Standard |
It is often used as a metal chelating agent and has good metal ion integration ability. Its chelation is mainly achieved through the formation of coordination bonds between the sulfhydryl group in dimercaptopropyl sulfonic acid and metal ions. Sulfhydryl group is a kind of functional group containing sulfur atoms, which has strong sulfur affinity and can form stable integrated complexes with metal ions.
DL-2,3-Dimercapto-1-propanesulfonic acid sodium salt monohydrate has been widely used in medical field. It can be used to treat moderate and severe lead poisoning, especially for children with lead poisoning. Sodium dimethylpropyl sulfonate promotes its excretion in the body by forming a stable complex with lead ion, thus playing a detoxification role. In addition, sodium dimercaptopropyl sulfonate can also be used to treat other heavy metal poisoning, such as bismuth, etc., has a certain detoxification effect.
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