Berberine Hydrochloride

Berberine hydrochloride, is an organic compound, chemical formula C20H18ClNO4, yellow crystalline powder, soluble in boiling water, slightly soluble in cold water, almost insoluble in cold alcohol, chloroform and ether, mainly used as antibacterial drugs, on dysentery bacillus, Escherichia coli, pneumococcus aureus, streptococcus, typhoid bacillus and amoeba have inhibitory effects. Clinical mainly used for intestinal infection and bacillary dysentery, also found that this product has anti-arrhythmia effect.

Appearance: yellow crystalline powder.

Solubility: easily soluble in boiling water, slightly soluble in cold water, almost insoluble in cold ethanol, chloroform and ether.

Berberine hydrochloride can effectively inhibit the proliferation of various cancer cells, promote apoptosis, and affect MAPK and Wnt/_beta_-catenin pathways.

Re na le lifeme tse ngata tsa boleng bo holimo tse nang le tšebelisano e tebileng, tse ka u fang lihlahisoa tsa boleng bo holimo le litheko tsa tlholisano. Hape re ka fana ka litheolelo bakeng sa ho reka ka bongata.'Me re sebelisana le lik'hamphani tse ngata tsa litsebi tse tsamaisang thepa, li ka isa lihlahisoa ka mokhoa o sireletsehileng le ka thelelo matsohong a hau. Nako ea ho fana e ka ba matsatsi a 3-20 ka mor'a hore ho netefatsoe tefo.

pharmacodynamics
The antibacterial spectrum is wide, and it has antibacterial effect on many kinds of gram-positive and gram-negative bacteria in vitro, including hemolytic streptococcus, Staphylococcus aureus and Vibrio cholerae. Meningococcus, Shigella dysentery, typhoid bacillus, diphtheria bacillus have strong inhibitory effect, low concentration of bacteriostasis, high concentration of bactericidal. It also has certain inhibitory effect on influenza virus, amoeba, leptospira and some skin fungi. In vitro experiments show that berberine can enhance the phagocytosis of leukocyte and hepatic reticuloendothelial system. Dysentery bacillus, hemolytic streptococcus, staphylococcus aureus and so on are easy to develop resistance to this product. There is no cross-resistance between this product and penicillin, streptomycin, etc.

pharmacokinetics
Poor oral absorption. After injection, the drug quickly enters the organs and tissues, and the blood concentration is maintained for a short time. The blood concentration after intramuscular injection was lower than the minimum inhibitory concentration. Drugs are widely distributed, mainly in the heart, bone, lung and liver. The retention time in the tissue is short, only a trace amount remains after 24 hours, most of the drugs are metabolized and cleared in the body, and the discharge in its original form within 48 hours only accounts for less than 5% of the dose.

According to recent reports, it is believed that this product can reduce the number of pili on the surface of the body, so that the bacteria can not attach to the human cells, and play a therapeutic role. This product also has an effect on Helicobacter, and can relieve gastritis, gastric and duodenal ulcer.

1. Na u feme kapa k'hamphani ea khoebo?
Re komnay e kopanyang indasteri le khoebo, ho fana ka ts'ebeletso e le 'ngoe.OEM e ka amoheloa.

2. O fana ka mehlala? Na ke mahala kapa ho feta?
Mehlala ea mahala. Tefiso ea thepa ea sampole e hloka ho lefuoa ka lehlakore la hau.

3. O na le litifikeiti tse amanang le taolo ea boleng?
Setifikeiti sa ISO 9001:2008 ho netefatsa boleng.

4. Ke fane ka eng ho fumana khotheishene?
Pls re tsebise ka mofuta oa sehlahisoa seo u se hlokang, bongata ba odara, aterese le litlhoko tse ikhethileng. Khotheishene e tla etsoa bakeng sa referense ea hau ka nako.

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