Cyclopentane chloride is a colorless transparent liquid at room temperature and pressure. Relative density (d420)1.0051, refractive index (ηD20)1.4512. Insoluble in water but miscible with common organic solvents. It has good chemical stability and is not easy to deteriorate under normal circumstances. It also shows good stability to oxidants and good solubility to many organic compounds.
Cyclopentane chloride is a pharmaceutical intermediate that can be used to prepare Palbociclib. Palbociclib(formally known as PD-0332991) is the result of a project initiated by researchers at Parke-Davis, which was later acquired by Pfizer. It first entered people's vision in 2012 at the SAN Antonio Breast Chemicalbook Cancer Conference (SABCS), and once it was released, it attracted widespread attention in the industry. Palbociclib is an oral inhibitor of cyclin-dependent kinases CDK4 and CDK6, which mainly acts by regulating cell cycle and prevents cells from G1 phase to S phase by inhibiting CDK4/6 activity, thus inhibiting DNA synthesis.
1. This product is mainly used as a reducing agent and imaging agent, for the preparation of oxime in organic synthesis, and as a raw material for the synthesis of anticancer drugs (hydroxyurea), sulfonamide drugs (Neosomin), anti-cold drugs and pesticides (Methomyl). It is used as a depolarizer in electrical analysis and as a non-colored short-term stopper in the synthetic rubber industry
2. For organic synthesis
3. Intermediates of organic synthesis.
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Molecular Formula | C5H9Cl |
Molar Mass | 104.58 |
Density | 1.005g/mLat 25°C(lit.) |
Smeltepunkt | -50 °C |
Boling Point | 114°C(lit.) |
Flash Point | 59°F |
Vannløselighet | 760 mg/L |
Solubility | 0.8g/l |
Vapor Presure | 35-45hPa at 20-25℃ |
Utseende | Flytende |
Specific Gravity | 1.01 |
Color | Colorless to Almost colorless |
BRN | 1900557 |
Storage Condition | Flammables area |
Refractive Index | n20/D 1.4512(lit.) |
Physical and Chemical Properties | Density 1.005 melting point -50°C boiling point 114°C refractive index 1.4502-1.4522 flash point 15°C water-soluble 760 mg/L |
Bruk | For Organic synthesis |
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