Camptothecin (CPT) is a cytotoxic quino line alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
1. Anti tumor effect.
2. Camptothecin can inhibit the proliferation of fibroblasts both in vivo and in vitro.
3. In addition, camptothecin has obvious inhibitory effect on herpesvirus.
4. In vivo, camptothecin is mainly excreted from bile and urine.
5. Camptothecin can induce chromosome aberration and is toxic.
6. Treatment of esophageal cancer, cardiac cancer.
7. Treatment of gastric cancer.
8. Treatment of primary liver cancer.
9. Treatment of psoriasis.
10. Treatment of skin warts.
ከፍተኛ ጥራት ያላቸውን ምርቶች እና ተወዳዳሪ ዋጋዎችን ሊያቀርብልዎ የሚችል ጥልቅ ትብብር ያለው ብዙ ከፍተኛ ጥራት ያላቸው ፋብሪካዎች አሉን። እና ለጅምላ ግዢ ቅናሾችን ልንሰጥ እንችላለን።እናም ከብዙ ፕሮፌሽናል ጭነት አስተላላፊ ኩባንያዎች ጋር እንተባበራለን፣ምርቶቹን በእጆችዎ ላይ ደህንነቱ በተጠበቀ ሁኔታ እናደርሳለን። የማስረከቢያ ጊዜ ክፍያው ከተረጋገጠ ከ3-20 ቀናት አካባቢ ነው።
መልክ | Crystalline Powder | ያሟላል። | Visual |
Color | Light Yellow | ያሟላል። | Visual |
ሽታ | Characteristic | ያሟላል። | Organoleptic |
Taste | Characteristic | ያሟላል። | Organoleptic |
Particle Size 100 | 100% pass 80 mesh | ያሟላል። | 80 Mesh Screen |
በማድረቅ ላይ ኪሳራ | 5% Max | 3.21% | CPh |
አመድ | 5%Max | 3.13% | CPh |
Part of Plant Used | Nut | ያሟላል። | / |
Solvent Extract | Water | ያሟላል። | / |
Excipient | 5%-10% Maltodextrin | ያሟላል። | / |
Chemical Control | |||
Heavy metals | NMT10ppm | ይስማማል። | Atomic Absorption |
Arsenic (As) | NMT 2ppm | ይስማማል። | Atomic Absorption |
Mercury(Hg) | NMT 1ppm | ይስማማል። | Atomic Absorption |
Lead (Pb) | NMT 2ppm | ይስማማል። | Atomic Absorption |
GMO Status | GMO Free | ይስማማል። | / |
Solvent Residual | Meet E.P Standard | ይስማማል። | Ph.Eur |
Pesticides Residues | Meet USP Standard | ይስማማል። | Gas Chromatography |
Benzo(a)pyrene | NMT 10ppb | ይስማማል። | GC-MS |
Sum of benzo(a)pyrene, benz(a)anthracene, benzo(b)fluoranthene and chrysene | NMT 50ppb | ይስማማል። | GC-MS |
Microbiological Control | |||
ጠቅላላ የሰሌዳ ብዛት | 10000cfu/g Max | ይስማማል። | AOAC |
Yeast & Mold | 300cfu/g Max | ይስማማል። | AOAC |
S. aureus | አሉታዊ | አሉታዊ | AOAC |
ኢ.ኮሊ | አሉታዊ | አሉታዊ | AOAC |
ሳልሞኔላ | አሉታዊ | አሉታዊ | AOAC |
Pseudomonas aeruginosa | አሉታዊ | አሉታዊ | USP |
1. ፋብሪካ ነህ ወይስ የንግድ ድርጅት?
እኛ ኢንዱስትሪን እና ንግድን የሚያዋህድ ኩባንያ ነን ፣አንድ ማቆሚያ አገልግሎት እየሰጠን ።OEM ተቀባይነት ሊኖረው ይችላል።
2. ናሙናዎችን ይሰጣሉ? ነፃ ነው ወይስ ተጨማሪ?
ነፃ ናሙናዎች፡ የናሙናውን የጭነት ክፍያ ከጎንዎ መከፈል አለበት።
3. ከጥራት ቁጥጥር ጋር የተያያዙ የምስክር ወረቀቶች አሎት?
ጥራትን ለማረጋገጥ ISO 9001: 2008 የምስክር ወረቀት.
4. ጥቅስ ለማግኘት ምን ማቅረብ አለብኝ?
Pls የሚፈልጉትን የምርት አይነት ፣የትእዛዝ ብዛት ፣አድራሻ እና የተወሰኑ መስፈርቶችን ያሳውቁን ።የዋጋ ጥቅሱ በጊዜ ውስጥ ለእርስዎ ማጣቀሻ ይደረጋል።
5. ምን ዓይነት የመክፈያ ዘዴ ይመርጣሉ? ምን ዓይነት ውሎች ተቀባይነት አላቸው?
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