Dutasteride

Dutasteride is a white crystalline solid chemical. The molecular formula is C27H30F6N2O2, the molecular weight is 528.53000, the density is 1.303 g/cm3, and the melting point is 242-250ºC.

Appearance and properties: white crystalline solid
Density: 1.303 g/cm3
Melting point: 242-250ºC
Boiling point: 620.3ºC at 760 mmHg
Flash point: 329ºC
Refractive index: 1.523
Vapor pressure: 0mmHg at 25°C
Insoluble in water, soluble in ethanol (44mg/ml), methanol (64mg/ml), polyethylene glycol 400(4mg/ml)

Testosterone is converted into dihydrotestosterone (DHT) by the action of 5α-reductase, and DHT can promote the growth and development of the prostate. There are two subtypes of 5α-reductase, type I isoenzyme and type II isoenzyme, of which type I isoenzyme has reproductive activity and type II isoenzyme is involved in the conversion of testosterone in skin and liver. This product is a relatively specific 5α-reductase inhibitor that forms an enzyme complex to inhibit type I and type II 5α-reductase isoenzymes, inhibiting the conversion of testosterone into DHT, thereby inhibiting the generation of androgenic hormone DHT, and therefore inhibiting the growth of the prostate in benign prostatic hyperplasia (BPH) patients. Daily 0.5mg, the DHT-lowering effect of the drug reaches its peak 1-2 weeks after taking the medicine, and the plasma DHT can be reduced by 85%-90%. Patients with enlarged prostate take 5mg of the drug daily, and the DHT is significantly reduced after 12 weeks.

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1. Dutasteride is more likely to cause a reduction in sperm count, and this effect can last for a fairly long time, even after discontinuation of the medication. Is Dutasteride likely to cause infertility? There is no conclusion in the report submitted by the US FDA. The incidence of sexual dysfunction is higher with Dutasteride than with 1 mg of Finasteride.

2. Furthermore, since there are many receptors for type 1 5α-reductase in the brain, the long-term effects of Dutasteride on type 1 5α-reductase inhibition in the brain are currently unknown. Finasteride, on the other hand, is less likely to have such effects because it specifically inhibits type 2 5α-reductase.

3. The US Food and Drug Administration (FDA) has already approved the use of Dutasteride in men with prostate enlargement, so if you are over 50 years old and have hair loss problems, the use of Dutasteride (Avodart, Dutasteride) can be considered.

4. The report submitted by the US FDA states that the amount of Dutasteride found in saliva or semen of men taking the medication will not affect the development of the embryo. However, pregnant women should avoid contact with broken Dutasteride capsules, as skin absorption may cause fetal malformations.