Amikacin CAS 37517-28-5

 Amikacin is made semisynthetically from kanamycin A. Interestingly, the L-hydroxyaminobutyryl amide (HABA) moiety attached to N-3 inhibits adenylation and phosphorylation in the distant amino sugar ring (at C-2′and C-3′), even though the HABA substituent is not where the enzymatic reaction takes place. This effect is attributed to decreased binding to the R factor-mediated enzymes.
 Amikacin, an aminoglycoside antibiotic, is a white or quasi-white powder or crystalline powder, almost odorless, tasteless.The mechanism of action is to act on the ribosome in bacteria, inhibit bacterial protein synthesis, and destroy the integrity of bacterial cell wall, resulting in bacterial cell membrane destruction, cell death.It is suitable for infection caused by Gelane-negative bacilli and penicillin resistant Staphylococcus aureus.

Amikacin is made semisynthetically from kanamycin A. Interestingly, the L-hydroxyaminobutyryl amide (HABA) moiety attached to N-3 inhibits adenylation and phosphorylation in the distant amino sugar ring (at C-2′and C-3′), even though the HABA substituent is not where the enzymatic reaction takes place. This effect is attributed to decreased binding to the R factor-mediated enzymes.

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