Amikacin is made semisynthetically from kanamycin A. Interestingly, the L-hydroxyaminobutyryl amide (HABA) moiety attached to N-3 inhibits adenylation and phosphorylation in the distant amino sugar ring (at C-2′and C-3′), even though the HABA substituent is not where the enzymatic reaction takes place. This effect is attributed to decreased binding to the R factor-mediated enzymes.
Amikacin, an aminoglycoside antibiotic, is a white or quasi-white powder or crystalline powder, almost odorless, tasteless.The mechanism of action is to act on the ribosome in bacteria, inhibit bacterial protein synthesis, and destroy the integrity of bacterial cell wall, resulting in bacterial cell membrane destruction, cell death.It is suitable for infection caused by Gelane-negative bacilli and penicillin resistant Staphylococcus aureus.
Amikacin is made semisynthetically from kanamycin A. Interestingly, the L-hydroxyaminobutyryl amide (HABA) moiety attached to N-3 inhibits adenylation and phosphorylation in the distant amino sugar ring (at C-2′and C-3′), even though the HABA substituent is not where the enzymatic reaction takes place. This effect is attributed to decreased binding to the R factor-mediated enzymes.
Tine mafekitori akawanda emhando yepamusoro nekubatana kwakadzama, ayo anogona kukupa zvigadzirwa zvemhando yepamusoro nemitengo yemakwikwi. Uye isu tinogonawo kupa zvidzikiso pakutenga kwakawanda. Uye isu tinobatirana nemakambani mazhinji ehunyanzvi ekutakura zvinhu, anogona kuendesa zvigadzirwa zvakachengeteka uye zvakanaka kumaoko ako. Nguva yekutumira inenge 3-20 mazuva mushure mekusimbiswa kwekubhadhara.
Analysis | Zvinotsanangurwa | Mhedzisiro |
Assay | ≥99% | 99.2% |
Chitarisiko | Upfu chena | Zvinoenderana |
Kurasika paKuomesa | ≤1.0% | 0.04% |
Ash | ≤1.0% | 0.1% |
As | ≤2.0ppm | <2.0ppm |
Pb | ≤2.0ppm | <2.0ppm |
Insoluble tsvina yemukati | ≤0.05% | Zvinoenderana |
Total Plate Count | ≤1000 cfu/g | Zvinoenderana |
Yeast &. Mold | ≤100 cfu/g | Zvinoenderana |
E.Coli | Negative | Negative |
Salmonella | Negative | Negative |
Mhedziso |
Gadzirisa USP Standard.
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Kuchengetedza mamiriro |
Chengetedza munzvimbo inotonhorera & yakaoma, Chengetedza kure nechiedza chakasimba uye kupisa.
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Sherufu hupenyu |
2 years pakachengetwa zvakanaka.
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