Basic Blue 9 also known as methylthioninium chloride, is a medication and dye. As a medication, it is mainly used to treat methemoglobinemia.Specifically, it is used to treat methemoglobin levels that are greater than 30% or in which there are symptoms despite oxygen therapy.[3] It has previously been used for cyanide poisoning and urinary tract infections, but this use is no longer recommended. It is typically given by injection into a vein.
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Chemical Name: Methylene blue
CAS No.: 61-73-4
Molecular Formula: C16H18ClN3S
Molecular weight: 319.85
Appearance: Dark green uniform powder
Strength: 107%
Methylene blue is employed as a medication for the treatment of methemoglobinemia. This can arise from ingestion of certain pharmaceuticals, toxins, or broad beans. Normally, through the NADH or NADPH dependent methemoglobin reductaseenzymes, methemoglobin is reduced back to hemoglobin. When large amounts of methemoglobin occur secondary to toxins, methemoglobin reductases are overwhelmed.
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Item Name | Requirements | Mga resulta |
Assay, percent | Min 98.0 | 99 |
Change color range | Passes | Passes |
Solubility in ethanol test | Passes | Passes |
Loss on drying , percent | Max 15.0 | 14.5 |
Sulfated ash (as SO4) , percent | Max 0.5 | 0.45 |
Arsenic(As), percent | Max 0.005 | 0.005 |
Cupper(Cu), percent | Max 0.003 | 0.025 |
Zinc(Zn), percent | Max 0.02 | 0.02 |
Methylene blue is a heterocyclic aromatic chemical compound with the chemical formula C16H18N3SCl. It has many uses in biology and chemistry; for example, it can be used as a stain and as a pharmaceutical drug. At room temperature it appears as a solid, odorless, dark green powder, that yields a blue solution when dissolved in water. The hydrated form has 3 molecules of water per unit of methylene blue. Methylene blue should not be confused with methyl blue, another histology stain, new methylene blue, nor with the methyl violets often used as pH indicators.
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