Carbomer 940

Carbomer copolymers e ka sebelisoa e le li-excipients, tse kang bioadhesives, emulsifiers, release modifiers, suspension agents, tablet adhesives, viscosifiers, joalo-joalo. Lisebelisoa tsa meriana kapa lisebelisoa tsa meriana li bua ka lintho tse ling tsa lik'hemik'hale, ntle le metsoako ea meriana, e sebelisoang ts'ebetsong ea meriana. Li-excipients tsa meriana ka kakaretso li bua ka metsoako e sa sebetseng litokisetsong tsa meriana, tse ka ntlafatsang botsitso, ho qhibiliha le ho sebetsa ha litokisetso tsa meriana. Li-excipients tsa meriana li boetse li ama mekhoa ea ho monya, ho ajoa, metabolism, le ho felisa (ADME) ea lithethefatsi tse sebelisoang hammoho.

Pontšo ea lihlahisoa

1. 1.Carbomer 940 ke phofo e tšoeu e hlephileng; Acid, hygroscopic le monko o khethehileng hanyenyane, o qhibilihang ka metsing, ethanol, glycerol. Khokahano e tloaelehileng ke 0.1% ~ 3.0%. Hobane limolek'hule tsa eona li na le palo e kholo ea lihlopha tsa carboxyl, tlhokomelo e khethehileng e lokela ho lefshoa ts'ebelisong ea litharollo tsa metsi ka mor'a ho se nke lehlakore ka alkali ho fokotsa ho teneha letlalong le lera la mucous.

2. 2.The neutralizing agent ea carbomer 940 e ka ba sodium hydroxide, potassium hydroxide, potassium bicarbonate, borax, amino acid, polar organic amines tse kang triethanolamine. Lauramine le stearamine li ka sebelisoa e le li-neutralizers tsamaisong e seng ea polar.

3. 3.Carbomer 940 ka boeona ha e fane ka ts'ebetso ea ho thibela likokoana-hloko le ho etsa sterilization ka ho toba, ke ka ho eketsa nako eo joala e lulang ka eona letlalong ho matlafatsa ts'oaetso ea likokoana-hloko le phello ea sterilization, 'me e ka etsa hore sehlahisoa se be le boikutlo bo botle ba letlalo, Carbomer 940 gel ha e tsitsa, e bonolo. ho holisa hlobo le ho lahleheloa ke viscosity kapele ha o pepesetsoa khanya ea letsatsi, ho eketsa antioxidant ho ka liehisa karabelo.

4. 4.Carbomer 940 transparency: Ho eketsoa ha hydrophilic non-electrolyte e matla (e kang ethanol) ho tla etsa hore tharollo ea polymer e phalle. Mekhoa e fapaneng ea ts'ebetso e tla lokisa gel ea Carbomer ethanol, 'me moeli o phahameng oa motsoako oa ethanol oa sehlahisoa se felileng o tla fapana. Ha motsoako oa ethanol o phahame haholo, gel e phethiloeng e tla hlahisa opalescence e nyenyane le ho fokotsa pepenene ea gel.

5. 5.Carbomer 940 viscosity: Tekanyo ea nts'etsopele ea limolek'hule, boleng ba PH, khatello ea electrolyte e tla ama viscosity ea Carbomer 940, ka mor'a ho se nke lehlakore, Carbomer hydrogel ke eona e ntle ka ho fetisisa pakeng tsa pH6 le 11, haeba pH <3 kapa pH> 12, viscosity. e fokotsehile. Ho ba teng ha electrolyte e matla ho ka boela ha fokotsa viscosity.

6. 6.Carbomer 940 e na le maikutlo a matsoai le li-cations, 'me palo ea karolo ena e lokela ho laoloa ha motsoako oa li-ion tse qhibilihang ka har'a motsoako o feta 0.1%. Haeba ho khoneha, lisebelisoa tse nang le acidic, neutral kapa alkaline li sebelisoa e le substrate e ka sehloohong ea lithethefatsi, metsi a deionized a sebelisoa, 'me letsoai le eketsoa ka mor'a ho se nke lehlakore ho utloisisa tekanyo ea tšusumetso ea letsoai tsamaisong. Li-ion tsa theko e phahameng (Ca, Mg, Fe, AI) li tla baka tšenyo e tebileng tsamaisong 'me li lokela ho tlosoa.

7. 7.Packing: E ​​ka tiisoa ka mokotleng oa polasetiki o thibelang mongobo le o sa keneleng moea, ebe o kenngoa ka lebokoseng la lebokose. Carbomer e na le thepa e matla ea hygroscopic. Ha u boloka, etsa bonnete ba hore u ela hloko ho tiisa, ela hloko li-clumps tsa ho kenngoa ha mongobo moeeng, haeba ho e-na le li-clumps tse fokolang, ka bonolo pat, e ka fetohang phofo e hlephileng, e ke ke ea ama phello ea thickening. Ha o nolofalitsoe, beha ka har'a setsi se sa keneleng moea se nang le desiccant.

Carbomer 940 e sebelisoa haholo ho emulsion, gel le lihlahisoa tse ling tsa tsamaiso ea metsi. E ka eketsa ka katleho viscosity le ho tsitsa ha sehlahisoa mme e fana ka phallo e ntle ea junifomo le botsitso.

Lifeme tseo re sebelisanang le tsona li na le thomello e kholo ea Carbomer 940, thomello e potlakileng le matsatsi a macha a tlhahiso. Sena se ka thusa barekisi le bareki ba bang ho reka Carbomer 940 ea boleng bo holimo ka letsatsi le lecha la tlhahiso ho tsoa ho rona. Re ke ke ra rekisa lihlahisoa haufi le letsatsi la ho felloa ke nako ho bareki joalo ka ba bang, hobane lipalangoang li nka nako, kahoo potoloho ea rona ea ho fana hangata e hlophisoa ka matsatsi a 10-15, 'me litaelo tse tlas'a lithane tsa 10 li tla romelloa matsatsing a 10.

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Setifikeiti ea Tlhahlobo-- Carbomer 940

Carbomer 940 ke sethethefatsi se sebelisoang haholo bakeng sa kalafo ea mafu a methapo eo phello ea eona e kholo e leng ho ntlafatsa ts'ebetso ea methapo ka ho laola ho lokolloa ha li-neurotransmitters.

Karolo e ka sehloohong ea carbomer 940 ke ho laola ho lokolloa ha li-neurotransmitters, tse bohlokoa bakeng sa phekolo ea mafu a kelello. Li-neurotransmitters ke lintho tsa bohlokoa bakeng sa phetiso ea tlhahisoleseling lipakeng tsa lisele tsa methapo, 'me carbomer 940 e khona ho laola ho lokolloa ha li-neurotransmitters, ka hona ho ntlafatsa ts'ebetso ea lisele tsa methapo le ho fokotsa matšoao a lefu.

Ho latela bongaka, carbomer 940 e sebelisoa haholo ho alafa mafu a mang a methapo, joalo ka lefu la Parkinson le lefu la Alzheimer's. Lefu la Parkinson ke lefu le tloaelehileng la methapo ea kutlo, bakuli ba bangata ba nang le ho satalla mesifa, ho thothomela le matšoao a mang, carbomer 940 e ka ntlafatsa matšoao ana ka katleho. Lefu la Alzheimer ke lefu la neurodegenerative leo ho lona bakuli ba lahleheloang ke mohopolo, bokhoni bo fokolang ba ho nahana le matšoao a mang, 'me carbomer 940 e ka ntlafatsa matšoao ana ka ho laola ho lokolloa ha li-neurotransmitters.

Ho phaella moo, carbomer 940 e na le litla-morao tse fokolang, empa lithethefatsi leha e le life li ka 'na tsa e-ba le liphello tse mpe, kahoo li lokela ho lateloa ha u sebelisa keletso ea ngaka, haeba ho se na ho ikamahanya le maemo ho batla tlhokomelo ea bongaka.

Carbomer 940 ke sethethefatsi se sebetsang hantle bakeng sa kalafo ea mafu a tsamaiso ea methapo, 'me mokhoa oa eona oa ts'ebetso ke haholo-holo ho ntlafatsa ts'ebetso ea methapo ka ho laola ho lokolloa ha li-neurotransmitters. Leha ho le joalo, ke habohlokoa ho hlokomela hore tšebeliso ea meriana leha e le efe e lokela ho etsoa tlas'a tataiso ea ngaka ho netefatsa polokeho le katleho.