Methotrexate

Methotrexate is an organic compound with the chemical formula C20H22N8O5. It is mainly used as an anti-folate anti-tumor drug. By inhibiting dihydrofolate reductase, it can hinder the synthesis of tumor cells and inhibit the growth and reproduction of tumor cells.

Appearance: yellow crystalline powder.

Solubility: Soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether.

Methotrexate is an antifolic acid antitumor drug, which has an inhibitory effect on many animal tumors. Experiments have shown that this drug works by competitive inhibition of dihydrofolate reductase. Dihydrofolate reductase is an important enzyme in DNA synthesis, especially in the conversion of folate to tetrahydrofolate and the methylation of deoxyuracil nucleoside to thymine nucleoside. This drug selectively acts on the DNA synthesis phase (that is, S phase), and is a cycle-specific drug. Recently, it has been suggested that this product has a second action point, that is, the G1/S transition phase, it can also inhibit the synthesis of interleukin-2 and inhibit the chemotactic effect of neutrophils, so it has immunosuppressive and anti-inflammatory effects. In large doses, it also has direct toxic effects on non-proliferating cells, especially hepatocytes, and CF is commonly used as an antidote in clinic.
The structure of methotrexate (MTX) is similar to folic acid, and the hydroxy group at 4 and the hydrogen at 10 NH are amino and CH3 respectively in MTX. MTX binds to dihydrofolate reductase, blocking the reduction of folate and dihydrofolate to activated tetrahydrofolate, thus inhibiting intracellular one-carbon transfer, affecting purine synthesis and deoxyuracil nucleotide conversion to deoxythymine nucleotide, and blocking DNA and RNA synthesis. MTX, at concentrations of 10-8mol/L in plasma, can effectively block the incorporation of deoxyuracil nucleotides into DNA via deoxythymine nucleotides, while inhibiting purine synthesis at concentrations of 10-7mol/L. The binding of MTX to dihydrofolate reductase is reversible but firm. The amount of dihydrofolate is 1000 times higher than MTX to resist MTX binding. In vitro, MTX can induce the differentiation of human chorionic epithelial cancer cells and increase the production of chorionic gonadotropin when the concentration is lower than that which completely inhibits DNA synthesis. MTX is a cell cycle specific drug, which mainly acts on S phase cells, has some effect on G1 phase, and has a delaying effect on G1/S.

اسان وٽ ڪيترائي اعلي معيار جا ڪارخانا آهن جن سان گڏ تعاون، جيڪو توهان کي اعلي معيار جي شين ۽ مقابلي واري قيمتن سان مهيا ڪري سگهي ٿو. ۽ اسان وڏي پئماني تي خريداري لاءِ رعايتون پڻ ڏئي سگھون ٿا. ۽ اسان ڪيترن ئي پروفيشنل فريٽ فارورڊنگ ڪمپنين سان تعاون ڪريون ٿا، پراڊڪٽس کي محفوظ ۽ آسانيءَ سان توهان جي هٿن تائين پهچائي سگهون ٿا. پهچائڻ وقت جي باري ۾ آهي 3-20 ڏينهن جي ادائيگي جي تصديق کان پوء.

1. ڇا توهان هڪ ڪارخانو يا هڪ واپاري ڪمپني آهي؟
اسان صنعت ۽ واپار کي ضم ڪرڻ واري ڪمپني آهيون، هڪ اسٽاپ سروس فراهم ڪري رهيا آهيون.OEM قبول ڪري سگهجي ٿو.

2. ڇا توهان نموني مهيا ڪندا آهيو؟ ڇا اهو مفت يا اضافي آهي؟
مفت نموني. نموني جي مال جي فيس توهان جي پاسي کان ادا ڪرڻ جي ضرورت آهي.

3. ڇا توهان وٽ ڪيفيت ڪنٽرول سان لاڳاپيل سرٽيفڪيٽ آهن؟
معيار کي يقيني بڻائڻ لاء ISO 9001: 2008 سرٽيفڪيشن.

4. مون کي اقتباس حاصل ڪرڻ لاء ڇا مهيا ڪرڻ گهرجي؟
مهرباني ڪري اسان کي پروڊڪٽ جي قسم جي ڄاڻ ڏيو جنهن جي توهان کي ضرورت آهي، آرڊر جي مقدار، ايڊريس ۽ مخصوص گهرجن. ڪوٽا توهان جي حوالي سان وقت ۾ ڪئي ويندي.

5. توهان ڪهڙي قسم جي ادائگي جو طريقو پسند ڪندا آهيو؟ ڪهڙي قسم جا شرط قبول ڪيا ويا آهن؟
قبول ٿيل پهچائڻ جون شرطون: FOB، CFR، CIF، EXW؛
قبول ٿيل ادائگي جي ڪرنسي: USD؛
قبول ٿيل ادائگي جو قسم: T/T، ويسٽرن يونين؛ Paypal، واپار جي ضمانت.
ڳالهائيندڙ ٻولي: انگريزي.