Methotrexate

Methotrexate is an organic compound with the chemical formula C20H22N8O5. It is mainly used as an anti-folate anti-tumor drug. By inhibiting dihydrofolate reductase, it can hinder the synthesis of tumor cells and inhibit the growth and reproduction of tumor cells.

Appearance: yellow crystalline powder.

Solubility: Soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether.

Methotrexate is an antifolic acid antitumor drug, which has an inhibitory effect on many animal tumors. Experiments have shown that this drug works by competitive inhibition of dihydrofolate reductase. Dihydrofolate reductase is an important enzyme in DNA synthesis, especially in the conversion of folate to tetrahydrofolate and the methylation of deoxyuracil nucleoside to thymine nucleoside. This drug selectively acts on the DNA synthesis phase (that is, S phase), and is a cycle-specific drug. Recently, it has been suggested that this product has a second action point, that is, the G1/S transition phase, it can also inhibit the synthesis of interleukin-2 and inhibit the chemotactic effect of neutrophils, so it has immunosuppressive and anti-inflammatory effects. In large doses, it also has direct toxic effects on non-proliferating cells, especially hepatocytes, and CF is commonly used as an antidote in clinic.
The structure of methotrexate (MTX) is similar to folic acid, and the hydroxy group at 4 and the hydrogen at 10 NH are amino and CH3 respectively in MTX. MTX binds to dihydrofolate reductase, blocking the reduction of folate and dihydrofolate to activated tetrahydrofolate, thus inhibiting intracellular one-carbon transfer, affecting purine synthesis and deoxyuracil nucleotide conversion to deoxythymine nucleotide, and blocking DNA and RNA synthesis. MTX, at concentrations of 10-8mol/L in plasma, can effectively block the incorporation of deoxyuracil nucleotides into DNA via deoxythymine nucleotides, while inhibiting purine synthesis at concentrations of 10-7mol/L. The binding of MTX to dihydrofolate reductase is reversible but firm. The amount of dihydrofolate is 1000 times higher than MTX to resist MTX binding. In vitro, MTX can induce the differentiation of human chorionic epithelial cancer cells and increase the production of chorionic gonadotropin when the concentration is lower than that which completely inhibits DNA synthesis. MTX is a cell cycle specific drug, which mainly acts on S phase cells, has some effect on G1 phase, and has a delaying effect on G1/S.

Kami adunay daghang mga de-kalidad nga pabrika nga adunay lawom nga kooperasyon, nga makahatag kanimo og taas nga kalidad nga mga produkto ug mga presyo sa kompetisyon. Ug makahatag usab kami og mga diskwento alang sa dinaghan nga pagpalit.Ug kami nakigtambayayong sa daghang mga propesyonal nga kompanya sa pagpasa sa kargamento, makahatud sa mga produkto nga luwas ug hapsay sa imong mga kamot. Delivery panahon mao ang mahitungod sa 3-20 ka adlaw human sa pagkumpirma sa pagbayad.

1. Ikaw ba usa ka pabrika o usa ka kompanya sa pamatigayon?
Kami usa ka compnay nga naghiusa sa industriya ug pamatigayon, nga naghatag ug one-stop service.OEM mahimong dawaton.

2. Naghatag ka ba og mga sampol? Libre ba kini o sobra?
Libre nga mga sample.Ang bayad sa kargamento sa sample kinahanglan nga ibayad sa imong kiliran.

3. Aduna ka bay mga sertipiko nga may kalabutan sa pagkontrol sa kalidad?
ISO 9001: 2008 nga sertipikasyon aron masiguro ang kalidad.

4. Unsa ang akong ihatag aron makakuha og kinutlo?
Pls ipahibalo kanamo ang tipo sa produkto nga imong gikinahanglan, gidaghanon sa pag-order, adres ug piho nga mga kinahanglanon. Ang kinutlo himuon alang sa imong pakisayran sa oras.

5. Unsa nga matang sa paagi sa pagbayad ang imong gusto? Unsang matanga sa mga termino ang gidawat?
Gidawat nga Delivery Terms: FOB, CFR, CIF, EXW;
Gidawat nga Bayad nga Salapi:USD;
Gidawat nga Uri sa Pagbayad: T / T, Western Union; Paypal, Trade Assurance.
Pinulongan nga Gisulti: English.