Levofloxacin Hydrochloride

Levofloxacin hydrochloride, an organic compound with the chemical formula C18H21ClFN3O4, is a quinolone antibacterial drug suitable for urinary and reproductive system infections caused by sensitive bacteria. These include simple and complex urinary tract infections, bacterial prostatitis, Neisseria gonorrhoeae urethritis or cervicitis (including those caused by enzyme producing strains), respiratory infections (including acute episodes of bronchial infections and lung infections caused by sensitive gram-negative bacilli), gastrointestinal infections (caused by Shigella, Salmonella, enterotoxigenic Escherichia coli, aeromonas hydrophila, Vibrio parahaemolyticus, etc.) It can also treat systemic infections such as typhoid fever, bone and joint infections, skin and soft tissue infections, and sepsis.

The main action mechanism of levofloxacin hydrochloride is to inhibit the activity of bacterial DNA rotase (bacterial topoisomerase II) and block bacterial DNA replication.
It has the characteristics of broad-spectrum antibacterial action and strong antibacterial effects. It has strong antibacterial activity against most enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella pneumoniae, Serratia species, Proteus species, Shigella species, Salmonella species, Citrobacter species, Acinetobacter species, and Pseudomonas aeruginosa, Haemophilus influenzae, and Neisseria gonorrhoeae, etc. gram-negative bacteria.
It also has good antibacterial effects against some methicillin-sensitive Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and hemolytic Streptococcus species, etc. gram-positive bacteria and Legionella species, Mycoplasma species, and Chlamydia species. However, its effect on anaerobic bacteria and enterococci is poor.

Levofloxacin hydrochloride is an oral active antibiotic that is active against both gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibited DNA rotase and topoisomerase IV. Levofloxacin hydrochloride can be used in the study of chronic periodontitis, airway inflammation and BK viremia

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This product is suitable for the following light and moderate infections caused by sensitive bacteria:
1. Respiratory system infections: acute bronchitis, acute exacerbation of chronic bronchitis, diffuse bronchiolitis, bronchiectasis with infection, pneumonia, tonsillitis (pharyngeal abscess);

2. Urinary system infections: pyelonephritis, complex urinary tract infections;

3. Genital system infections: acute prostatitis, acute epididymitis, endometritis, endometritis, pelvic inflammatory disease (suspected anaerobic infection can be used with metronidazole);

4. Soft tissue infections: infectious pustular disease, cellulitis, lymphangitis (lymphadenitis), subcutaneous abscess, perianal abscess;

5. Intestinal infections: bacillary dysentery, infectious enteritis, salmonellosis, typhoid and paratyphoid fever;

6. Sepsis, leukopenia and immunocompromised patients with various infections;

7. Other infections: mastitis, injuries, burns and postoperative wound infections, peritonitis (if necessary, metronidazole can be used together), cholecystitis, cholangitis, bone and joint infections, and infections in the five major organs.

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