Ademetionine 1, 4-Butanedisulfonate

Ademetionine 1, 4-Butanedisulfonate CAS 101020-79-5 API

Product nomen:
Ademetionine 1, 4-Butanedisulfonate
Gradus:
Pharmaceutical/Reagent grade
Possessiones:
cerussa
Stipare:
25kg/orum
MOQ:
1 kilo
Repono:Frigus siccum
Fasciae vita:Annis II

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Ademetionine 1,4-Butanedisulfonate(SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain.

Applicationem

1.Ademetionine 1,4-Butanedisulfonate(SAMe) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAMe. Although these anabolic reactions occur throughout the body, most SAMe is produced and consumed in the liver.

2.Ademetionine 1,4-Butanedisulfonate attached to the methionine sulfur atom in SAMe is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAMe to various substrates such as nucleic acids, proteins, and lipids.

3.In bacteria, SAMe is bound by the SAMe riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.

commoda

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Specification

Test Items		Specifications	Proventus
Aspectus		White to off-white Powder	White crystalline powder
HPLC		The retention time of the major peak corresponds to the reference sample	Complied
Specific Rotation		+28°~+34°	+30
Water		3.0% MAX	2.2%
PH (0.4% AQUEOUS SOLUTION)		1.8 -2.5	2.2
Residue on ignition		≤0.5%	0.3%
Heavy Metals		Not more than 10 ppm	Complied
Content of Ademetionine(HPLC)		50.0 - 54.0%	50.1%
Content of 1,4-butanedisulfonate		46.0%-49.0%	48.6%
S,S-isomer		≥60%	77.5%
Related substances(HPLC):
- ADENINE		0.5% MAX.	0.1%
- S-ADENOSYL-L-HOMOCYSTEINE		0.5% MAX.	0.05%
- METHYLTHIOADENOSINE		0.5% MAX.	0.2%
OTHER INDIVIDUAL IMPURITY		0.1% MAX.	0.09%
- TOTAL OTHER IMPURITIES		1.0% MAX.	0.4%
- TOTAL IMPURITIES		2.5% MAX.	0.8%
ASSAY		≥97.0%	98.7%
Bacterual endtoxin		≤0.25EU/mg	Complied
Microbiology	Total Aerobic Count	≤200cfu/g	Complied
	Total Combined Yeasts and Molds Count	≤100cfu/g	Complied
	E. coli	Absent/10g	Complied
conclusio		Complies with Enterprise standard

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