Acetaminophen (paracetamol)

Acetaminophen, also known as paracetamol or acetaminophen, is an organic compound with the chemical formula C8H9NO2, which is the metabolite of phenacetin in the body. It reduces the synthesis and release of prostaglandin PGE1, bradykinin and histamine by inhibiting prostaglandin synthetase in the hypothalamus thermoregulatory center. Acetaminophen is commonly used to relieve headaches, toothaches, menstrual cramps, muscle aches, and other common types of pain, as well as to reduce fever caused by a cold, flu, or other illness. Because it is less irritating to the stomach, it is generally considered safer than other over-the-counter pain medications, especially for children and pregnant women. Unlike other common analgesics such as aspirin and ibuprofen, acetaminophen has a lower anti-inflammatory effect and is therefore a safer option for those who cannot use non-steroidal anti-inflammatory drugs (NSAIDs). But excessive use of acetaminophen can cause serious side effects, especially liver damage. Therefore, dosage guidelines must be strictly followed when used, and combination with other medicines containing acetaminophen must be avoided.

Density: 1.293g/cm3.

Melting point: 168-172℃.

Appearance: Colorless crystalline powder.

Solubility: Soluble in methanol, ethanol, dichloroethylene, acetone and ethyl acetate, slightly soluble in ether and hot water, almost insoluble in cold water, its solubility in water increases with the increase of temperature. The solubility is 7.21 g/kg at 0°C and about 14 mg/ml at 20°C, and it is insoluble in petroleum ether, pentane and benzene.

Stability: Relatively stable, prolonged exposure to heat or light may lead to degradation.

Acetaminophen (paracetamol) is an antipyretic and analgesic drug. By inhibiting cyclooxygenase, acetaminophen can selectively inhibit the synthesis of prostaglandins in the hypothalamic thermoregulatory center, leading to peripheral vascular dilation and sweating, thus achieving antipyretic effect. Its antipyretic effect is similar to that of aspirin. It plays an analgesic role by inhibiting the synthesis and release of prostaglandins, etc. and raising the pain threshold. It is a peripheral analgesic drug with a weaker effect than aspirin and is only effective for light and moderate pain. This product has no obvious anti-inflammatory effect.

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indication
It is used for cold fever, joint pain, neuralgia and migraine, cancer pain and pain relief after operation. It can also be used in patients who are allergic to, intolerant to, or unsuitable for aspirin use (chickenpox, hemophilia, and other bleeding disorders).

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