Lidocaine hydrochloride is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine hydrochloride. Approximately 90% of Lidocaine hydrochloride administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2,6-dimethylaniline.
1. Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.
2.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.
3. Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias if amiodarone is not available or contraindicated.
4. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.
Peb muaj ntau lub Hoobkas zoo nrog kev koom tes sib sib zog nqus, uas tuaj yeem muab koj cov khoom zoo thiab cov nqi sib tw. Thiab peb tseem tuaj yeem muab cov luv nqi rau kev yuav khoom ntau.Thiab peb koom tes nrog ntau lub tuam txhab xa khoom xa tuaj, tuaj yeem xa cov khoom lag luam kom nyab xeeb thiab ntseeg nkaws rau koj txhais tes. Lub sij hawm xa tuaj yog li 3-20 hnub tom qab tau txais kev pom zoo ntawm kev them nyiaj.
1. Koj puas yog lub Hoobkas lossis tuam txhab lag luam?
Peb yog ib qho kev sib koom ua ke kev lag luam thiab kev lag luam, muab kev pabcuam ib-nres.OEM tuaj yeem txais.
2. Koj puas muab cov qauv? Puas yog dawb lossis ntxiv?
Cov qauv dawb.Cov qauv tus nqi thauj khoom yuav tsum tau them los ntawm koj sab.
3. Koj puas muaj daim ntawv pov thawj ntsig txog kev tswj xyuas zoo?
ISO 9001: 2008 ntawv pov thawj los xyuas kom meej qhov zoo.
4. Kuv yuav muab dab tsi kom tau txais cov lus hais?
Pls qhia peb txog cov khoom lag luam uas koj xav tau, xaj kom muaj nuj nqis, chaw nyob thiab cov kev xav tau tshwj xeeb.Cov lus hais yuav ua rau koj siv sijhawm.
5. Hom kev them nqi twg koj nyiam? Cov nqe lus twg raug lees txais?
Txais Cov Lus Cog Tseg: FOB, CFR, CIF, EXW;
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