Nadolol is a non-selective beta-adrenergic receptor antagonist with antihypertensive and antiarrhythmic activity. White crystalline powder. Melting point 124-136℃, soluble in alcohol, slightly soluble in chloroform, insoluble in acetone, benzene.
- Nadolol is a long-acting non-selective β-blocker with no intrinsic sympathetitic activity and membrane stabilization, and its β-receptor blocking strength is 3 to 9 times that of propranolol, which is a powerful antiarrhythmic drug. Nadolol can block the myocardial β1 receptor, produce negative frequency, negative Chemicalbook conduction, negative muscle strength of the three negative effects, but also block the airway and vascular smooth muscle β2 receptor, can reduce the rest and exercise systolic and diastolic blood pressure, 40mg or 80mg per tablet, the initial dose of 20~40mg. The usual dosage is 40~80mg/d.
- Antiarrhythmic drugs. Nadolol is used to treat high blood pressure, angina, arrhythmia, migraine, hyperthyroidism.
Tha mòran fhactaraidhean àrd-inbhe againn le co-obrachadh domhainn, a bheir dhut toraidhean àrd-inbhe agus prìsean farpaiseach. Agus is urrainn dhuinn cuideachd lasachaidhean a thoirt seachad airson mòr-cheannach. Tha an ùine lìbhrigidh timcheall air 3-20 latha às deidh dearbhadh pàighidh.
Product Name: | NADOLOL |
Synonyms: | 1-(tert-butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy);1-(tert-Butylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2-propanol;1-(tert-bytylamino)-3-((5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-naphthyl)oxy)-2;2,3-cis-1,2,3,4-tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naph;2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol;2,3-cis-1,2,3,4-tetrahydro-5-(2-hydroxy-3-(tert-butylamino)propoxy)-2,3-naphth;2,3-diol;2,3-Naphthalenediol, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- |
CAS: | 42200-33-9 |
MF: | C17H27NO4 |
MW: | 309.4 |
EINECS: | 255-706-3 |
Product Categories: | RITALIN |
Mol File: | 42200-33-9.mol |
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NADOLOL Chemical Properties |
Puing leaghaidh | 125-130°C |
Goil puing | 449.67°C (rough estimate) |
dùmhlachd | 1.0449 (rough estimate) |
clàr-amais refractive | 1.5420 (estimate) |
teòthachd stòraidh. | Refrigerator |
so-thuigsinn | Slightly soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in acetone. |
pka | 9.67(at 25℃) |
foirm | Solid |
dath | White to Off-White |
Solubility uisge | 8.30g/L(25 ºC) |
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