Metoclopramide Hydrochloride

Metoclopramide Hydrochloride is an antiemetics that can be used in chemotherapy, radiotherapy, surgery, craniocerebral injury, sequelae of brain trauma, naval operations, and drug-induced vomiting. It can also be used for the symptomatic treatment of nausea and vomiting symptoms of acute gastroenteritis, biliary tract pancreas, urosis and other diseases. It can also be used before diagnostic duodenal intubation to facilitate smooth intubation. Gastrointestinal barium X-ray examination can alleviate nausea and vomiting reaction; Promote the passage of barium.

Metoclopramide Hydrochloride is a dopamine-2 (D2) receptor antagonist, and has a receptor excitatory effect of 5-tibiotryptamine 4 (5-HT4), and has a mild inhibitory effect on 5-HT3 receptors. It can act on the dopamine receptor in the emetic chemoceptive area (CTZ) of the medulla oblong and raise the threshold of CTZ, which has a powerful central antiemetic effect. Metoclopramide Hydrochloride can also block hypothalamic dopamine receptors, inhibit prolactin inhibitory factor, and promote the secretion of prolactin, so it has certain prolactin effect. The inhibitory effect on other parts of the center is relatively small, has a weak stabilizing effect, and less causes hypnotic effect. The effect on gastrointestinal tract is mainly in the upper digestive tract, promoting the movement of stomach and upper intestinal segment; Increase the tension of the resting gastrointestinal muscle, increase the tension and contraction amplitude of the lower esophageal muscle, and increase the lower end of the esophageal pressure. Block gastroesophageal reflux, strengthen stomach and esophageal peristalsis, enhance the clearance ability of esophageal contents, promote gastric empting, promote the relaxation of pylorus, duodenum and upper jejunum, and form the functional coordination between the stomach body and upper gut. These effects can also enhance the antinausea effect of this product. The effect of this product on small intestine and colon delivery is uncertain.

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