Bisacodyl is a irritant laxative that mainly acts on the large intestine. After oral administration of bisacodyl, the products decomposed by intestinal bacteria and the drug itself have a strong stimulating effect on the intestinal wall, which can stimulate the sensory nerve endings to produce parasympathetic reflex, causing intestinal reflex peristalsis and leading to defecation. Bisacodyl can also stimulate local axon reflexes and segmental reflexes, and produce extensive colonic peristalsis. Therefore, bisacodyl may be effective for patients with ganglion blockage or spinal cord damage (paraplegia, polio). At the same time, bisacodyl can inhibit the absorption of sodium, chlorin and water in the colon, increase the volume of the intestine, and cause reflex defecation. Clinical application has confirmed that there is no damage to the heart, lung, liver, kidney, hematopoietic system and immune system after using bisacodyl.
Bisacodyl is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Bisacodyl is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movemen.
Bisacodyl is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Bisacodyl is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movemen.
Bisacodyl is a stimulant laxative. It stimulates the muscles in the wall of the small intestine and colon to generate a bowel movement. It also alters water and electrolyte levels inintestines, increasing the level of fluids which also produce a laxative-like effect.
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Items | Standard | Result |
Appearance | A white or almost white powder | Conforms |
Assay(on dried basis) | 99%-101%w/w | 99.55%w/w |
Identification | To match working standard | Similar to the working standard |
Appearance of solution | As per EP | Conforms |
Optical rotation | between -0.1 to +0.1 | +0.04 |
Individual impurity | Not more intense than 0.5% | 0.09% |
Total impurities | Not more intense than 1.0% | 0.28% |
Water | 3.4%w/w - 4.0%w/w | 3.9%w/w |
Sulphated ash | Not more than 0.1%w/w | 0.03%w/w |
Conclusion: Conform to above specifications. |
Bisacodyl (INN) is an organic compound that is used as a laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction as well as part of bowel preparation before medical examinations, such as for a colonoscopy.Bisacodyl is a derivative of triphenylmethane.
Bisacodyl is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Bisacodyl is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movemen.
Bisacodyl is a stimulant laxative. It stimulates the muscles in the wall of the small intestine and colon to generate a bowel movement. It also alters water and electrolyte levels inintestines, increasing the level of fluids which also produce a laxative-like effect.
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