Tadalafil

Tadalafil is a selective reversible inhibitor of cyclic guanosine phosphate (cGMP) specific phosphodiesterase 5 (PDE5). When sexual stimulation leads to the local release of nitric oxide, PDE5 is inhibited by tadalafil, which increases the level of cGMP in the penis sponge, which leads to smooth muscle relaxation, blood flow into the penis tissue, and erection; Without sexual stimulation, the drug may not work.

Erectile dysfunction and pulmonary hypertension.

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