4- Acetaminophen /Paracetamol

4- Acetaminophen /Paracetamol is a metabolite of , regulates central prostaglandin synthase by inhibiting hypothalamic body temperature. Reduce the synthesis and release of prostaglandin PGE1, bradykinin and histamine. PGE1 mainly acts on the nerve center.Mainly used for amino acid infusion,due to special wettability, also used in cold cream,osmetics. Serine constitute the human body of several kinds of essential amino acid of protein a, for the construction of protein has a very important role. Paracetamol is used for the relief of pains associated with many parts of the body. It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin in patients in whom excessive gastric acid secretion or prolongation of bleeding time may be a concern.

The antipyretic and analgesic acetaminophen, this product is a metabolite of phen acetin, regulates central prostaglandin synthase by inhibiting hypothalamic body temperature. Reduce the synthesis and release of prostaglandin PGE1, bradykinin and histamine. 
PGE1 mainly acts on the nerve center. Its decrease will lead to a decrease in the central body temperature setting point, and the body surface temperature sensor will feel relatively hot, and then through nerve regulation, it will cause peripheral blood vessels to dilate and sweat to achieve antipyretic effect, which inhibits the central nervous system. 

1.Acetaminophen /Paracetamol is the most commonly used non-anti-inflammatory antipyretic analgesic, antipyretic and similar to aspirin, analgesic effect is weak, no anti-inflammatory anti-rheumatism, is the best variety of  drugs.
2.Acetaminophen /Paracetamol is especially suitable for patients who cannot use carboxylic acid drugs
3.Acetaminophen /Paracetamol used for colds, toothache and other diseases
4.Acetaminophen /Paracetamol is also an intermediate in organic synthesis and a photographic chemical.

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Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug.

Function:
Paracetamol is suitable for alleviating mild to moderate pain, such as fever, headache, joint pain, neuralgia, migraine, dysmenorrhea, etc. caused by a cold. It is especially suitable for patients who cannot use carboxylic acid drugs.

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