(1R,3R)-2, 2-dimethyl-3 -(2-methylprop-1-ene-1-yl) cyclopropane-1-carboxylic acid is an organic compound also known as (R,R) -me-CPA.
Nature:
(R,R) -Me-CPA is a solid compound. It has a colorless to light yellow appearance and has a distinctive odor. The compound is soluble in organic solvents such as ethanol and dichloromethane.
1. (R,R) -Me-CPA is mainly used as a catalyst in chiral synthesis, especially in asymmetric nucleophilic addition reactions and asymmetric oxidation reactions.
2. It is an important intermediate for the synthesis of chiral insecticides with high efficiency, low toxicity and beneficial to environmental protection. Like permethrin, allethrin, proparthrin.
3. Organic synthetic raw materials, used for the synthesis of photocuring agent 184, anti-pregnancy drug 392 and the treatment of vampire insect disease drug praziquantel.
Preparation:
The preparation method of (R,R) -Me-CPA is generally obtained by photooxidation and silver catalyzed reaction. The specific steps may include the addition of carbon dioxide, the dissolution of substrates and the addition of reactants.
Safety information:
(R,R) -Me-CPA currently has no clear risk record. Proper laboratory practices must be followed when using chemicals, including wearing appropriate personal protective equipment such as gloves and safety glasses, and avoiding inhalation, ingestion, or skin contact. In case of contact with the substance, flush immediately with plenty of water and seek medical assistance. When storing and handling this compound, follow the relevant safe operating procedures.
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Molecular Formula | C10H16O2 |
Molar Mass | 168.23 |
Density | 0.9934 (rough estimate) |
Melting Point | 17-21 °C |
Boling Point | 255.81°C (rough estimate) |
Specific Rotation(α) | D25 +14.16° (c = 1.554 in abs alc) |
Appearance | Light yellow liquid |
Color | Clear colorless to yellow |
BRN | 4904351 |
pKa | 4.90±0.33(Predicted) |
Storage Condition | 0-6°C |
Refractive Index | n20/D 1.477 |
MDL | MFCD01941572 |
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